Design of experiment assisted concurrent enantioseparation of bupropion and hydroxybupropion by high‐performance thin‐layer chromatography

A simple and efficient high‐performance thin‐layer chromatographic method was developed for chiral separation of rac‐bupropion (BUP) and its active metabolite rac‐hydroxybupropion (HBUP). Design of experiment (DoE)‐based optimization was adopted instead of a conventional trial‐and‐error approach. Th...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2017-02, Vol.29 (2), p.80-88
Hauptverfasser:	Bhatt, Nejal M., Chavada, Vijay D., Sanyal, Mallika, Shrivastav, Pranav S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Box Behnken model Bupropion - analogs & derivatives Bupropion - chemistry bupropion hydroxybupropion chiral separation Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer design of experiment high‐performance thin‐layer chromatography Research Design Stereoisomerism Tartrates - chemistry
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