Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study

Background Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. Objectives Safety a...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2017-01, Vol.76 (1), p.33-39
Hauptverfasser:	Bissonnette, Robert, MD, Poulin, Yves, MD, Drew, Janice, MPH, Hofland, Hans, PhD, Tan, Jerry, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl-coenzyme A carboxylase inhibitor acne vulgaris Acne Vulgaris - diagnosis Acne Vulgaris - drug therapy Administration, Cutaneous Adolescent Adult Dermatology Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Humans inflammatory lesions investigator global assessment local skin reactions Male noninflammatory lesions olumacostat glasaretil Patient Selection Prospective Studies Reference Values Sebum - drug effects Severity of Illness Index Treatment Outcome Tretinoin - administration & dosage Young Adult
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