The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation

Mounting evidence suggests that constitutively active androgen receptor (AR) splice variants, typified by AR-V7, are associated with poor prognosis and resistance to androgen deprivation therapy in prostate cancer patients. However, mechanisms governing the generation of AR splice variants are not f...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-01, Vol.483 (1), p.271-276
Hauptverfasser:	Nakata, Daisuke, Nakao, Shoichi, Nakayama, Kazuhide, Araki, Shinsuke, Nakayama, Yusuke, Aparicio, Samuel, Hara, Takahito, Nakanishi, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals AR-V7 Castration-resistant prostate cancer Cell Line, Tumor DDX39A DDX39B DEAD-box RNA Helicases - chemistry Gene Expression Regulation, Neoplastic Gene Silencing Genetic Variation Humans Male Oligonucleotide Array Sequence Analysis Prostatic Neoplasms - metabolism Rats Receptors, Androgen - genetics RNA - analysis RNA, Messenger - metabolism RNA, Small Interfering - metabolism Transcriptome UAP56 URH49
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