Levothyroxine sodium revisited: A wholistic structural elucidation approach of new impurities via HPLC-HRMS/MS, on-line H/D exchange, NMR spectroscopy and chemical synthesis

[Display omitted] •A multitude of levothyroxine sodium impurities new to literature are characterized via HPLC-HRMS/MS and On-line H/D exchange.•5 major LT4 impurities are identified via synthesis or isolation of the reference substance and characterization with 1D and 2D-NMR.•CID fragmentation mech...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-02, Vol.135, p.140-152
Hauptverfasser:	Ruggenthaler, M., Grass, J., Schuh, W., Huber, C.G, Reischl, R.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Deuterium Exchange Measurement - methods Drug Contamination HDX LC-MS Levothyroxine Magnetic Resonance Spectroscopy - methods Mass Spectrometry - methods On-line H/D Exchange Pharmaceutical impurities Tandem Mass Spectrometry - methods Thyroid hormone Thyroxine - analysis Thyroxine - chemical synthesis
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