Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE−/− mice

Berberine (BBR), one of the main bioactive compounds in Rhizoma coptidis, has multiple pharmacological activities. It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters. Therefore, in the present study, we used a...

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Veröffentlicht in:	International immunopharmacology 2017-02, Vol.43, p.195-202
Hauptverfasser:	Feng, Min, Zou, Zongyao, Zhou, Xia, Hu, Yinran, Ma, Hang, Xiao, Yubo, Li, Xuegang, Ye, Xiaoli
Format:	Artikel
Sprache:	eng
Schlagworte:	8-cetylberberine Animals Anti-inflammatory Anti-Inflammatory Agents - therapeutic use Antioxidant Antioxidants - therapeutic use Aorta - drug effects Aorta - pathology Apolipoproteins E - genetics Atherosclerosis Atherosclerosis - drug therapy Berberine Berberine - analogs & derivatives Berberine - therapeutic use Cell Nucleus - metabolism Cricetinae Cytokines - metabolism Disease Models, Animal Drugs, Chinese Herbal Humans Inflammation Mediators - metabolism Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Protein Transport
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