A novel method for the determination of chemical purity and assay of menaquinone-7. Comparison with the methods from the official USP monograph

[Display omitted] •HPLC UV method for simultaneous determination of MK7 purity and assay was developed.•The proposed methodology can be applied for MK7 samples of different purity.•Low time, solvent and sample consumption, high selectivity and accuracy of the method.•The method is superior to the me...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-02, Vol.135, p.116-125
Hauptverfasser:	Jedynak, Łukasz, Jedynak, Maria, Kossykowska, Magdalena, Zagrodzka, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Assay Chemical purity Chemistry, Pharmaceutical - methods Chromatography, High Pressure Liquid - methods Degradation studies Drug Contamination HPLC Menaquinone-7 Pharmacopoeias as Topic - standards Photolysis Spectrophotometry, Ultraviolet - methods United States Vitamin K 2 - analogs & derivatives Vitamin K 2 - analysis Vitamin K 2 - metabolism
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