Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas
Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe,...
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| Veröffentlicht in: | Journal of dermatology 2017-06, Vol.44 (6), p.690-694 |
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| container_title | Journal of dermatology |
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| creator | Kagimoto, Yoshiko Yamasaki, Kenshi Shimada‐Ohmori, Ryoko Nan, Liu Numata, Yukikazu Aiba, Setsuya |
| description | Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma. |
| doi_str_mv | 10.1111/1346-8138.13726 |
| format | Article |
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The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.13726</identifier><identifier>PMID: 28026039</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>algogenic substance ; Benign ; Calcitonin gene-related peptide ; Case reports ; Dinoprostone - metabolism ; Female ; Fibroids ; Humans ; leiomyoma ; Leiomyoma - complications ; Leiomyoma - metabolism ; Middle Aged ; Pain ; Pain - etiology ; PGE2 ; Prostaglandin E2 ; Serotonin ; Skin Neoplasms - complications ; Skin Neoplasms - metabolism ; Smooth muscle ; TRPV Cation Channels - metabolism ; Tumors ; VR1</subject><ispartof>Journal of dermatology, 2017-06, Vol.44 (6), p.690-694</ispartof><rights>2016 Japanese Dermatological Association</rights><rights>2016 Japanese Dermatological Association.</rights><rights>Copyright © 2017 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3256-c4ded68bdace9a66722bb6d3f9b44f5c0aaa3b8d6692306109e099abc153046a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.13726$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.13726$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28026039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kagimoto, Yoshiko</creatorcontrib><creatorcontrib>Yamasaki, Kenshi</creatorcontrib><creatorcontrib>Shimada‐Ohmori, Ryoko</creatorcontrib><creatorcontrib>Nan, Liu</creatorcontrib><creatorcontrib>Numata, Yukikazu</creatorcontrib><creatorcontrib>Aiba, Setsuya</creatorcontrib><title>Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma.</description><subject>algogenic substance</subject><subject>Benign</subject><subject>Calcitonin gene-related peptide</subject><subject>Case reports</subject><subject>Dinoprostone - metabolism</subject><subject>Female</subject><subject>Fibroids</subject><subject>Humans</subject><subject>leiomyoma</subject><subject>Leiomyoma - complications</subject><subject>Leiomyoma - metabolism</subject><subject>Middle Aged</subject><subject>Pain</subject><subject>Pain - etiology</subject><subject>PGE2</subject><subject>Prostaglandin E2</subject><subject>Serotonin</subject><subject>Skin Neoplasms - complications</subject><subject>Skin Neoplasms - metabolism</subject><subject>Smooth muscle</subject><subject>TRPV Cation Channels - metabolism</subject><subject>Tumors</subject><subject>VR1</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPxCAUhYnR6PhYuzMkbtxUeRSmLI2Or5joQteE0ltF21KhHZ1_L-OoCzeSm0BuvntyOBehfUqOaTonlOcyKygvjimfMrmGJr-ddTQhvBAZy8l0C23H-EIIU4KSTbTFCsIk4WqCXu99dIObA7Y-BGjM4HyHfY3npnNN412FA1joBx9wHMth0QPFpqtwH3wczFOT3q7DM4bhow8Q43L83Q3PuDepn6oB59uFb03cRRu1aSLsfd876PFi9nB2ld3eXV6fnd5mljMhM5tXUMmirIwFZaScMlaWsuK1KvO8FpYYY3hZVFIqxomkRAFRypSWCk5yafgOOlrpJo9vI8RBty5aaJJX8GPUtBCcp5IyoYd_0Bc_hi6501QRIRSRgibqZEXZ9OkYoNZ9cK0JC02JXu5BL1PXy9T11x7SxMG37li2UP3yP8EnQKyAd9fA4j89fXM-Wwl_Aidskvs</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Kagimoto, Yoshiko</creator><creator>Yamasaki, Kenshi</creator><creator>Shimada‐Ohmori, Ryoko</creator><creator>Nan, Liu</creator><creator>Numata, Yukikazu</creator><creator>Aiba, Setsuya</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas</title><author>Kagimoto, Yoshiko ; Yamasaki, Kenshi ; Shimada‐Ohmori, Ryoko ; Nan, Liu ; Numata, Yukikazu ; Aiba, Setsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3256-c4ded68bdace9a66722bb6d3f9b44f5c0aaa3b8d6692306109e099abc153046a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>algogenic substance</topic><topic>Benign</topic><topic>Calcitonin gene-related peptide</topic><topic>Case reports</topic><topic>Dinoprostone - metabolism</topic><topic>Female</topic><topic>Fibroids</topic><topic>Humans</topic><topic>leiomyoma</topic><topic>Leiomyoma - complications</topic><topic>Leiomyoma - metabolism</topic><topic>Middle Aged</topic><topic>Pain</topic><topic>Pain - etiology</topic><topic>PGE2</topic><topic>Prostaglandin E2</topic><topic>Serotonin</topic><topic>Skin Neoplasms - complications</topic><topic>Skin Neoplasms - metabolism</topic><topic>Smooth muscle</topic><topic>TRPV Cation Channels - metabolism</topic><topic>Tumors</topic><topic>VR1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kagimoto, Yoshiko</creatorcontrib><creatorcontrib>Yamasaki, Kenshi</creatorcontrib><creatorcontrib>Shimada‐Ohmori, Ryoko</creatorcontrib><creatorcontrib>Nan, Liu</creatorcontrib><creatorcontrib>Numata, Yukikazu</creatorcontrib><creatorcontrib>Aiba, Setsuya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kagimoto, Yoshiko</au><au>Yamasaki, Kenshi</au><au>Shimada‐Ohmori, Ryoko</au><au>Nan, Liu</au><au>Numata, Yukikazu</au><au>Aiba, Setsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>44</volume><issue>6</issue><spage>690</spage><epage>694</epage><pages>690-694</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28026039</pmid><doi>10.1111/1346-8138.13726</doi><tpages>5</tpages></addata></record> |
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| subjects | algogenic substance Benign Calcitonin gene-related peptide Case reports Dinoprostone - metabolism Female Fibroids Humans leiomyoma Leiomyoma - complications Leiomyoma - metabolism Middle Aged Pain Pain - etiology PGE2 Prostaglandin E2 Serotonin Skin Neoplasms - complications Skin Neoplasms - metabolism Smooth muscle TRPV Cation Channels - metabolism Tumors VR1 |
| title | Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas |
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