Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth
Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta...
Gespeichert in:
| Veröffentlicht in: | Placenta (Eastbourne) 2017-06, Vol.54, p.24-29 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 29 |
|---|---|
| container_issue | |
| container_start_page | 24 |
| container_title | Placenta (Eastbourne) |
| container_volume | 54 |
| creator | Clifton, V.L Cuffe, J Moritz, K.M Cole, T.J Fuller, P.J Lu, N.Z Kumar, S Chong, S Saif, Z |
| description | Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity. |
| doi_str_mv | 10.1016/j.placenta.2016.12.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1853352921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0143400416306713</els_id><sourcerecordid>1853352921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-d980467730f4524dacee5b3b7e0feb07ee10639fd25e6124e55520f3d9df6e753</originalsourceid><addsrcrecordid>eNqFUstu1DAUtRCIDgO_UHnJZoIfcTJhgUBVeUiVkKCsLY99PfXg2MF2WvUb-GmcTocFG1a2pfPwPecidE5JQwnt3hyaySsNoaiG1XdDWUNo_wStqOBswylhT9GK0JZvWkLaM_Qi5wMhZGgpe47O2LaCuehX6Pc3uHVw9xZf3wBO0QOOFo-zL26q95OHx3s_66hjKk5HZ3ACDVOJCbscbUxjxi5gZdRUXNjjEnGpcqMqkEIlQ7h1KYaxSmEVFvZ-9uoBauFBPcW7cvMSPbPKZ3j1eK7Rj4-X1xefN1dfP325-HC10e12KBszbEnb9T0nthWsNfWLIHZ81wOxsCM9ACUdH6xhAjrKWhBCMGK5GYztoBd8jV4fdacUf82Qixxd1uC9ChDnLOlWcC7YwGiFdkeoTjHnBFZOyY0q3UtK5FKEPMhTSHIpQlIml2zX6PzRY96NYP7STslXwPsjAOqktYIks3YQNBhXwy3SRPd_j3f_SGjvgtPK_4R7yIc4L-nXeWSuBPl9WYdlG2jHSddTzv8AB521Hw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1853352921</pqid></control><display><type>article</type><title>Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Clifton, V.L ; Cuffe, J ; Moritz, K.M ; Cole, T.J ; Fuller, P.J ; Lu, N.Z ; Kumar, S ; Chong, S ; Saif, Z</creator><creatorcontrib>Clifton, V.L ; Cuffe, J ; Moritz, K.M ; Cole, T.J ; Fuller, P.J ; Lu, N.Z ; Kumar, S ; Chong, S ; Saif, Z</creatorcontrib><description>Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2016.12.017</identifier><identifier>PMID: 28017357</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adaptation, Physiological ; Animals ; Epigenesis, Genetic ; Female ; Fetal Development ; Fetus ; Glucocorticoid receptor isoforms ; Humans ; Internal Medicine ; Obstetrics and Gynecology ; Placenta ; Placenta - metabolism ; Pregnancy ; Pregnancy Complications - metabolism ; Protein Isoforms - metabolism ; Receptors, Glucocorticoid - metabolism ; Sex</subject><ispartof>Placenta (Eastbourne), 2017-06, Vol.54, p.24-29</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-d980467730f4524dacee5b3b7e0feb07ee10639fd25e6124e55520f3d9df6e753</citedby><cites>FETCH-LOGICAL-c489t-d980467730f4524dacee5b3b7e0feb07ee10639fd25e6124e55520f3d9df6e753</cites><orcidid>0000-0001-8062-7281 ; 0000-0002-4892-6748</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400416306713$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28017357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clifton, V.L</creatorcontrib><creatorcontrib>Cuffe, J</creatorcontrib><creatorcontrib>Moritz, K.M</creatorcontrib><creatorcontrib>Cole, T.J</creatorcontrib><creatorcontrib>Fuller, P.J</creatorcontrib><creatorcontrib>Lu, N.Z</creatorcontrib><creatorcontrib>Kumar, S</creatorcontrib><creatorcontrib>Chong, S</creatorcontrib><creatorcontrib>Saif, Z</creatorcontrib><title>Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Epigenesis, Genetic</subject><subject>Female</subject><subject>Fetal Development</subject><subject>Fetus</subject><subject>Glucocorticoid receptor isoforms</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - metabolism</subject><subject>Protein Isoforms - metabolism</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Sex</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1DAUtRCIDgO_UHnJZoIfcTJhgUBVeUiVkKCsLY99PfXg2MF2WvUb-GmcTocFG1a2pfPwPecidE5JQwnt3hyaySsNoaiG1XdDWUNo_wStqOBswylhT9GK0JZvWkLaM_Qi5wMhZGgpe47O2LaCuehX6Pc3uHVw9xZf3wBO0QOOFo-zL26q95OHx3s_66hjKk5HZ3ACDVOJCbscbUxjxi5gZdRUXNjjEnGpcqMqkEIlQ7h1KYaxSmEVFvZ-9uoBauFBPcW7cvMSPbPKZ3j1eK7Rj4-X1xefN1dfP325-HC10e12KBszbEnb9T0nthWsNfWLIHZ81wOxsCM9ACUdH6xhAjrKWhBCMGK5GYztoBd8jV4fdacUf82Qixxd1uC9ChDnLOlWcC7YwGiFdkeoTjHnBFZOyY0q3UtK5FKEPMhTSHIpQlIml2zX6PzRY96NYP7STslXwPsjAOqktYIks3YQNBhXwy3SRPd_j3f_SGjvgtPK_4R7yIc4L-nXeWSuBPl9WYdlG2jHSddTzv8AB521Hw</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Clifton, V.L</creator><creator>Cuffe, J</creator><creator>Moritz, K.M</creator><creator>Cole, T.J</creator><creator>Fuller, P.J</creator><creator>Lu, N.Z</creator><creator>Kumar, S</creator><creator>Chong, S</creator><creator>Saif, Z</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8062-7281</orcidid><orcidid>https://orcid.org/0000-0002-4892-6748</orcidid></search><sort><creationdate>20170601</creationdate><title>Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth</title><author>Clifton, V.L ; Cuffe, J ; Moritz, K.M ; Cole, T.J ; Fuller, P.J ; Lu, N.Z ; Kumar, S ; Chong, S ; Saif, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-d980467730f4524dacee5b3b7e0feb07ee10639fd25e6124e55520f3d9df6e753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Epigenesis, Genetic</topic><topic>Female</topic><topic>Fetal Development</topic><topic>Fetus</topic><topic>Glucocorticoid receptor isoforms</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - metabolism</topic><topic>Protein Isoforms - metabolism</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Sex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clifton, V.L</creatorcontrib><creatorcontrib>Cuffe, J</creatorcontrib><creatorcontrib>Moritz, K.M</creatorcontrib><creatorcontrib>Cole, T.J</creatorcontrib><creatorcontrib>Fuller, P.J</creatorcontrib><creatorcontrib>Lu, N.Z</creatorcontrib><creatorcontrib>Kumar, S</creatorcontrib><creatorcontrib>Chong, S</creatorcontrib><creatorcontrib>Saif, Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clifton, V.L</au><au>Cuffe, J</au><au>Moritz, K.M</au><au>Cole, T.J</au><au>Fuller, P.J</au><au>Lu, N.Z</au><au>Kumar, S</au><au>Chong, S</au><au>Saif, Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>54</volume><spage>24</spage><epage>29</epage><pages>24-29</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><abstract>Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28017357</pmid><doi>10.1016/j.placenta.2016.12.017</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8062-7281</orcidid><orcidid>https://orcid.org/0000-0002-4892-6748</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4004 |
| ispartof | Placenta (Eastbourne), 2017-06, Vol.54, p.24-29 |
| issn | 0143-4004 1532-3102 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1853352921 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptation, Physiological Animals Epigenesis, Genetic Female Fetal Development Fetus Glucocorticoid receptor isoforms Humans Internal Medicine Obstetrics and Gynecology Placenta Placenta - metabolism Pregnancy Pregnancy Complications - metabolism Protein Isoforms - metabolism Receptors, Glucocorticoid - metabolism Sex |
| title | Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T21%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Review:%20The%20role%20of%20multiple%20placental%20glucocorticoid%20receptor%20isoforms%20in%20adapting%20to%20the%20maternal%20environment%20and%20regulating%20fetal%20growth&rft.jtitle=Placenta%20(Eastbourne)&rft.au=Clifton,%20V.L&rft.date=2017-06-01&rft.volume=54&rft.spage=24&rft.epage=29&rft.pages=24-29&rft.issn=0143-4004&rft.eissn=1532-3102&rft_id=info:doi/10.1016/j.placenta.2016.12.017&rft_dat=%3Cproquest_cross%3E1853352921%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1853352921&rft_id=info:pmid/28017357&rft_els_id=S0143400416306713&rfr_iscdi=true |