MicroRNA‐184 Modulates Human Central Nervous System Lymphoma Cells Growth and Invasion by Targeting iASPP

ABSTRACT Central nervous system lymphoma (CNSL) remains a diagnostical and therapeutical challenge. MiRNAs post‐transcriptionally regulate expression of targeted mRNAs through binding to their 3′ UTR to inhibit their translation or promote their degradation. Oncoprotein inhibitory member of the ASPP...

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Veröffentlicht in:	Journal of cellular biochemistry 2017-09, Vol.118 (9), p.2645-2653
Hauptverfasser:	Liang, Xiao‐gong, Meng, Wen‐tong, Hu, Lian‐jie, Li, Lin, Xing, Hongyun, Xie, Gan, Wang, An‐qiong, Jia, Yong‐qian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 3' Untranslated Regions AKT protein ASPP Biochemistry Brain Cell Proliferation Cell survival Central nervous system CENTRAL NERVOUS SYSTEM LYMPHOMA Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - pathology Degradation Female Humans Inhibition Inhibitors Intervention Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism INVASION Invasiveness Kinases Lymphoma Lymphoma - genetics Lymphoma - metabolism Lymphoma - pathology Male MicroRNAs - genetics MicroRNAs - metabolism miRNA MIR‐184 Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nervous system p53 Protein Post-transcription PROLIFERATION Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleic acid RNA RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Signal transduction Signal Transduction - genetics Survival Tissues Transcription Tumor Cells, Cultured Tumor suppressor genes
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