A Rare Diagnosis: Recognizing and Managing Fungal Tenosynovitis of the Hand and Upper Extremity
Purpose Fungal infections involving the tenosynovium of the upper extremity are uncommon and are often misdiagnosed. This study evaluates the epidemiology, diagnosis, treatment, and outcomes of patients with fungal tenosynovitis of the upper extremity over a 20-year period. Methods A retrospective r...
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description | Purpose Fungal infections involving the tenosynovium of the upper extremity are uncommon and are often misdiagnosed. This study evaluates the epidemiology, diagnosis, treatment, and outcomes of patients with fungal tenosynovitis of the upper extremity over a 20-year period. Methods A retrospective review of all culture-confirmed cases of fungal tenosynovitis of the upper extremity treated between 1990 and 2013 at a single institution was performed. Clinical data included patient and epidemiologic risk factors, causative fungal organism, surgical management, antimicrobial regimen, recurrence rates, and outcomes. Results There were 10 patients (9 female, 1 male) who met the inclusion criteria. The mean patient age was 60 years (range, 47–76 y). Identified pathogens included Histoplasma capsulatum (7), Coccidioides posadasii/immitis (2), and Cryptococcus neoformans (1). Eight patients were on immunosuppressant medications at the time of diagnosis. The most common clinical presentation was subacute localized pain, swelling, and erythema consistent with tenosynovitis. The diagnosis was delayed by a median of 6 months (range, 0–48 mo). The most helpful diagnostic imaging studies included magnetic resonance imaging and ultrasound. All patients were treated with extensive surgical synovectomy and debridement. Seven patients were treated by a single surgery, whereas 3 required multiple consecutive debridements (2, 7, and 10 surgeries). The mean course of initial antimicrobial therapy was 8.2 months (range, 3–12 mo). Clinical recurrence was noted in 3 patients (30%) during a median follow-up period of 46 months (range, 7–250 mo). Both patients with Coccidioides infection incurred recurrence. Conclusions Although uncommon, surgeons and clinicians should consider a diagnosis of fungal tenosynovitis among immunocompromised patients with signs of mild tenosynovitis and should consider operative debridement and biopsy. Although the majority of patients were successfully treated with surgical debridement and antimicrobial therapy, a recurrence rate of 30% highlights the need for close post-treatment follow-up. Type of study/level of evidence Therapeutic V. |
doi_str_mv | 10.1016/j.jhsa.2016.11.014 |
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This study evaluates the epidemiology, diagnosis, treatment, and outcomes of patients with fungal tenosynovitis of the upper extremity over a 20-year period. Methods A retrospective review of all culture-confirmed cases of fungal tenosynovitis of the upper extremity treated between 1990 and 2013 at a single institution was performed. Clinical data included patient and epidemiologic risk factors, causative fungal organism, surgical management, antimicrobial regimen, recurrence rates, and outcomes. Results There were 10 patients (9 female, 1 male) who met the inclusion criteria. The mean patient age was 60 years (range, 47–76 y). Identified pathogens included Histoplasma capsulatum (7), Coccidioides posadasii/immitis (2), and Cryptococcus neoformans (1). Eight patients were on immunosuppressant medications at the time of diagnosis. The most common clinical presentation was subacute localized pain, swelling, and erythema consistent with tenosynovitis. The diagnosis was delayed by a median of 6 months (range, 0–48 mo). The most helpful diagnostic imaging studies included magnetic resonance imaging and ultrasound. All patients were treated with extensive surgical synovectomy and debridement. Seven patients were treated by a single surgery, whereas 3 required multiple consecutive debridements (2, 7, and 10 surgeries). The mean course of initial antimicrobial therapy was 8.2 months (range, 3–12 mo). Clinical recurrence was noted in 3 patients (30%) during a median follow-up period of 46 months (range, 7–250 mo). Both patients with Coccidioides infection incurred recurrence. Conclusions Although uncommon, surgeons and clinicians should consider a diagnosis of fungal tenosynovitis among immunocompromised patients with signs of mild tenosynovitis and should consider operative debridement and biopsy. Although the majority of patients were successfully treated with surgical debridement and antimicrobial therapy, a recurrence rate of 30% highlights the need for close post-treatment follow-up. Type of study/level of evidence Therapeutic V.</description><identifier>ISSN: 0363-5023</identifier><identifier>EISSN: 1531-6564</identifier><identifier>DOI: 10.1016/j.jhsa.2016.11.014</identifier><identifier>PMID: 28011032</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Antifungal Agents - therapeutic use ; Combined Modality Therapy ; Debridement ; Diagnostic Imaging ; Female ; Fungal ; Humans ; Immunocompromised Host ; infection ; Male ; Middle Aged ; Mycoses - diagnosis ; Mycoses - microbiology ; Mycoses - therapy ; Orthopedics ; Retrospective Studies ; tenosynovitis ; Tenosynovitis - diagnosis ; Tenosynovitis - microbiology ; Tenosynovitis - therapy ; Treatment Outcome ; upper extremity ; Upper Extremity - microbiology</subject><ispartof>The Journal of hand surgery (American ed.), 2017-02, Vol.42 (2), p.e77-e89</ispartof><rights>American Society for Surgery of the Hand</rights><rights>2017 American Society for Surgery of the Hand</rights><rights>Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-7477a5d642bae96cd469829c7ca0c8fdf208bdbb82b614f36c95301f2baf699b3</citedby><cites>FETCH-LOGICAL-c326t-7477a5d642bae96cd469829c7ca0c8fdf208bdbb82b614f36c95301f2baf699b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhsa.2016.11.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28011032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Shaughnessy, Maureen A., MD</creatorcontrib><creatorcontrib>Tande, Aaron J., MD</creatorcontrib><creatorcontrib>Vasoo, Shawn, MD</creatorcontrib><creatorcontrib>Enzler, Mark J., MD</creatorcontrib><creatorcontrib>Berbari, Elie F., MD</creatorcontrib><creatorcontrib>Shin, Alexander Y., MD</creatorcontrib><title>A Rare Diagnosis: Recognizing and Managing Fungal Tenosynovitis of the Hand and Upper Extremity</title><title>The Journal of hand surgery (American ed.)</title><addtitle>J Hand Surg Am</addtitle><description>Purpose Fungal infections involving the tenosynovium of the upper extremity are uncommon and are often misdiagnosed. This study evaluates the epidemiology, diagnosis, treatment, and outcomes of patients with fungal tenosynovitis of the upper extremity over a 20-year period. Methods A retrospective review of all culture-confirmed cases of fungal tenosynovitis of the upper extremity treated between 1990 and 2013 at a single institution was performed. Clinical data included patient and epidemiologic risk factors, causative fungal organism, surgical management, antimicrobial regimen, recurrence rates, and outcomes. Results There were 10 patients (9 female, 1 male) who met the inclusion criteria. The mean patient age was 60 years (range, 47–76 y). Identified pathogens included Histoplasma capsulatum (7), Coccidioides posadasii/immitis (2), and Cryptococcus neoformans (1). Eight patients were on immunosuppressant medications at the time of diagnosis. The most common clinical presentation was subacute localized pain, swelling, and erythema consistent with tenosynovitis. The diagnosis was delayed by a median of 6 months (range, 0–48 mo). The most helpful diagnostic imaging studies included magnetic resonance imaging and ultrasound. All patients were treated with extensive surgical synovectomy and debridement. Seven patients were treated by a single surgery, whereas 3 required multiple consecutive debridements (2, 7, and 10 surgeries). The mean course of initial antimicrobial therapy was 8.2 months (range, 3–12 mo). Clinical recurrence was noted in 3 patients (30%) during a median follow-up period of 46 months (range, 7–250 mo). Both patients with Coccidioides infection incurred recurrence. Conclusions Although uncommon, surgeons and clinicians should consider a diagnosis of fungal tenosynovitis among immunocompromised patients with signs of mild tenosynovitis and should consider operative debridement and biopsy. Although the majority of patients were successfully treated with surgical debridement and antimicrobial therapy, a recurrence rate of 30% highlights the need for close post-treatment follow-up. Type of study/level of evidence Therapeutic V.</description><subject>Aged</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Debridement</subject><subject>Diagnostic Imaging</subject><subject>Female</subject><subject>Fungal</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>infection</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycoses - diagnosis</subject><subject>Mycoses - microbiology</subject><subject>Mycoses - therapy</subject><subject>Orthopedics</subject><subject>Retrospective Studies</subject><subject>tenosynovitis</subject><subject>Tenosynovitis - diagnosis</subject><subject>Tenosynovitis - microbiology</subject><subject>Tenosynovitis - therapy</subject><subject>Treatment Outcome</subject><subject>upper extremity</subject><subject>Upper Extremity - microbiology</subject><issn>0363-5023</issn><issn>1531-6564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS0EotPCD7BAXrJJ8LMTJ0EIqSotRSpCKu3acpyX1CFjT-2kYvj6OprCggULy7Z07pPeuYS8AZYDA_l-zMe7qHOe3jlAzqB4RjZQCshkKYvnZMOEFFnJuDgixzGOjCVSlC_JEa8ZABN8Q9QpvdYB6WerB-ejjR_oNRo_OPvbuoFq19Fv2ulh_VwsbtATvcEE7p1_sLON1Pd0vkN6uZLrud3tMNDzX3PArZ33r8iLXk8RXz_dJ-T24vzm7DK7-v7l69npVWYEl3NWFVWly04WvNXYSNMVsql5Yyqjman7ruesbru2rXkroeiFNE0pGPQJ72XTtOKEvDvM3QV_v2Cc1dZGg9OkHfolKqhLXtVlDSKh_ICa4GMM2KtdsFsd9gqYWsWqUa1i1SpWAagkNoXePs1f2i12fyN_TCbg4wHAtOWDxaCisegMdjagmVXn7f_nf_onbibrrNHTT9xjHP0SXPKnQEWumPqxVrs2mwplTVNU4hFhvJ5D</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>O'Shaughnessy, Maureen A., MD</creator><creator>Tande, Aaron J., MD</creator><creator>Vasoo, Shawn, MD</creator><creator>Enzler, Mark J., MD</creator><creator>Berbari, Elie F., MD</creator><creator>Shin, Alexander Y., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>A Rare Diagnosis: Recognizing and Managing Fungal Tenosynovitis of the Hand and Upper Extremity</title><author>O'Shaughnessy, Maureen A., MD ; Tande, Aaron J., MD ; Vasoo, Shawn, MD ; Enzler, Mark J., MD ; Berbari, Elie F., MD ; Shin, Alexander Y., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-7477a5d642bae96cd469829c7ca0c8fdf208bdbb82b614f36c95301f2baf699b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Debridement</topic><topic>Diagnostic Imaging</topic><topic>Female</topic><topic>Fungal</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>infection</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycoses - diagnosis</topic><topic>Mycoses - microbiology</topic><topic>Mycoses - therapy</topic><topic>Orthopedics</topic><topic>Retrospective Studies</topic><topic>tenosynovitis</topic><topic>Tenosynovitis - diagnosis</topic><topic>Tenosynovitis - microbiology</topic><topic>Tenosynovitis - therapy</topic><topic>Treatment Outcome</topic><topic>upper extremity</topic><topic>Upper Extremity - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Shaughnessy, Maureen A., MD</creatorcontrib><creatorcontrib>Tande, Aaron J., MD</creatorcontrib><creatorcontrib>Vasoo, Shawn, MD</creatorcontrib><creatorcontrib>Enzler, Mark J., MD</creatorcontrib><creatorcontrib>Berbari, Elie F., MD</creatorcontrib><creatorcontrib>Shin, Alexander Y., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of hand surgery (American ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Shaughnessy, Maureen A., MD</au><au>Tande, Aaron J., MD</au><au>Vasoo, Shawn, MD</au><au>Enzler, Mark J., MD</au><au>Berbari, Elie F., MD</au><au>Shin, Alexander Y., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Rare Diagnosis: Recognizing and Managing Fungal Tenosynovitis of the Hand and Upper Extremity</atitle><jtitle>The Journal of hand surgery (American ed.)</jtitle><addtitle>J Hand Surg Am</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>42</volume><issue>2</issue><spage>e77</spage><epage>e89</epage><pages>e77-e89</pages><issn>0363-5023</issn><eissn>1531-6564</eissn><abstract>Purpose Fungal infections involving the tenosynovium of the upper extremity are uncommon and are often misdiagnosed. This study evaluates the epidemiology, diagnosis, treatment, and outcomes of patients with fungal tenosynovitis of the upper extremity over a 20-year period. Methods A retrospective review of all culture-confirmed cases of fungal tenosynovitis of the upper extremity treated between 1990 and 2013 at a single institution was performed. Clinical data included patient and epidemiologic risk factors, causative fungal organism, surgical management, antimicrobial regimen, recurrence rates, and outcomes. Results There were 10 patients (9 female, 1 male) who met the inclusion criteria. The mean patient age was 60 years (range, 47–76 y). Identified pathogens included Histoplasma capsulatum (7), Coccidioides posadasii/immitis (2), and Cryptococcus neoformans (1). Eight patients were on immunosuppressant medications at the time of diagnosis. The most common clinical presentation was subacute localized pain, swelling, and erythema consistent with tenosynovitis. The diagnosis was delayed by a median of 6 months (range, 0–48 mo). The most helpful diagnostic imaging studies included magnetic resonance imaging and ultrasound. All patients were treated with extensive surgical synovectomy and debridement. Seven patients were treated by a single surgery, whereas 3 required multiple consecutive debridements (2, 7, and 10 surgeries). The mean course of initial antimicrobial therapy was 8.2 months (range, 3–12 mo). Clinical recurrence was noted in 3 patients (30%) during a median follow-up period of 46 months (range, 7–250 mo). Both patients with Coccidioides infection incurred recurrence. Conclusions Although uncommon, surgeons and clinicians should consider a diagnosis of fungal tenosynovitis among immunocompromised patients with signs of mild tenosynovitis and should consider operative debridement and biopsy. Although the majority of patients were successfully treated with surgical debridement and antimicrobial therapy, a recurrence rate of 30% highlights the need for close post-treatment follow-up. Type of study/level of evidence Therapeutic V.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28011032</pmid><doi>10.1016/j.jhsa.2016.11.014</doi></addata></record> |
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subjects | Aged Antifungal Agents - therapeutic use Combined Modality Therapy Debridement Diagnostic Imaging Female Fungal Humans Immunocompromised Host infection Male Middle Aged Mycoses - diagnosis Mycoses - microbiology Mycoses - therapy Orthopedics Retrospective Studies tenosynovitis Tenosynovitis - diagnosis Tenosynovitis - microbiology Tenosynovitis - therapy Treatment Outcome upper extremity Upper Extremity - microbiology |
title | A Rare Diagnosis: Recognizing and Managing Fungal Tenosynovitis of the Hand and Upper Extremity |
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