Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9

Atrichia and sparse hair phenotype cause distress to many patients. Ectodermal dysplasia-9 (ED-9) is a congenital condition characterized by hypotrichosis and nail dystrophy without other disorders, and Hoxc13 is a pathogenic gene for ED-9. However, mice carrying Hoxc13 mutation present several othe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2017-01, Vol.26 (1), p.184-191
Hauptverfasser:	Han, Kai, Liang, Liuping, Li, Li, Ouyang, Zhen, Zhao, Bentian, Wang, Qi, Liu, Zhaoming, Zhao, Yu, Ren, Xiaoshuai, Jiang, Fei, Lai, Chengdan, Wang, Kepin, Yan, Sen, Huang, Liang, Guo, Lin, Zeng, Kang, Lai, Liangxue, Fan, Nana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Body Weight CRISPR-Cas Systems Disease Models, Animal Ectodermal Dysplasia - genetics Ectodermal Dysplasia - pathology Female Fetus - metabolism Fetus - pathology Fibroblasts - metabolism Fibroblasts - pathology Hair Follicle - metabolism Hair Follicle - pathology Homeodomain Proteins - antagonists & inhibitors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Male Mutation - genetics Sequence Homology, Nucleic Acid Skin - metabolism Skin - pathology Swine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!