Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity

Activity-dependent transcription has emerged as a major source of gene products that regulate neuronal excitability, connectivity, and synaptic properties. However, the elongation rate of RNA polymerases imposes a significant temporal constraint for transcript synthesis, in particular for long genes...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-12, Vol.92 (6), p.1266-1278
Hauptverfasser:	Mauger, Oriane, Lemoine, Frédéric, Scheiffele, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	activity-dependent gene expression Animals Blotting, Western Ca2+/calmodulin-dependent protein kinase Calcium-Calmodulin-Dependent Protein Kinases - metabolism CaMK Gene expression Gene Expression Regulation Genomes Genomics Hippocampus - metabolism immediate early gene intron retention Introns Kinetics Mice Neocortex - metabolism NMDA receptor Ontology plasticity Poly A - metabolism Real-Time Polymerase Chain Reaction Receptors, N-Methyl-D-Aspartate - metabolism Retention Reverse Transcriptase Polymerase Chain Reaction Ribosomes RNA Splicing RNA Transport RNA, Messenger - metabolism RNA, Ribosomal Sequence Analysis, RNA Signal Transduction splicing synapse Transcriptome
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