The human tRNA-modifying protein, TRIT1, forms amyloid fibers in vitro

TRIT1 is a highly conserved tRNA isopentenyl transferase that modifies a subset of tRNAs in human cells and is a candidate tumor suppressor in lung cancer in certain ethnic populations. The yeast homologue, Mod5, has similar tRNA-modifying functions in the cytoplasm and is required for the transcrip...

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Veröffentlicht in:	Gene 2017-05, Vol.612, p.19-24
Hauptverfasser:	Waller, T.J., Read, D.F., Engelke, D.R., Smaldino, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - metabolism Amino Acid Sequence Amyloid - biosynthesis Amyloid fibers Humans In Vitro Techniques Isopentenyl transferase Mod5 Molecular Sequence Data Prion RNA binding RNA, Transfer - metabolism Sequence Homology, Amino Acid TRIT1 tRNA gene mediated silencing tRNA modification
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