Influence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel

Proton pump inhibitors (PPIs) at low doses can effectively prevent gastrointestinal bleeding due to aspirin and are widely used in Japan for gastroprotection in patients taking anti-platelet agents. We examined the influence of different PPIs at low doses administered concomitantly or separately on...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2017-04, Vol.43 (3), p.333-342
Hauptverfasser:	Furuta, Takahisa, Sugimoto, Mitsushige, Kodaira, Chise, Nishino, Masafumi, Yamade, Mihoko, Uotani, Takahiro, Sahara, Shu, Ichikawa, Hitomi, Kagami, Takuma, Iwaizumi, Moriya, Hamaya, Yasushi, Osawa, Satoshi, Sugimoto, Ken, Umemura, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cardiology Cytochrome P-450 CYP2C19 - genetics Drug Interactions Drug Therapy, Combination Female Healthy Volunteers Hematology Humans Japan Male Medicine Medicine & Public Health Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacology Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - pharmacology Rabeprazole - administration & dosage Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Ticlopidine - pharmacology Time Factors
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