A Single Point Mutation in Mitochondrial Hsp70 Cochaperone Mge1 Gains Thermal Stability and Resistance

Mge1, a yeast homologue of Escherichia coli GrpE, is an evolutionarily conserved homodimeric nucleotide exchange factor of mitochondrial Hsp70. Temperature-dependent reversible structural alteration from a dimeric to a monomeric form is critical for Mge1 to act as a thermosensor. However, very limit...

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Veröffentlicht in:Biochemistry (Easton) 2016-12, Vol.55 (51), p.7065-7072
Hauptverfasser: Marada, Adinarayana, Karri, Srinivasu, Singh, Swati, Allu, Praveen Kumar, Boggula, Yerranna, Krishnamoorthy, Thanuja, Guruprasad, Lalitha, V Sepuri, Naresh Babu
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Sprache:eng
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