Effects of high‐intensity physical training on muscle fiber characteristics in poststroke patients
ABSTRACT Introduction Stroke is a leading cause of disability worldwide. High‐intensity physical training can improve muscle strength and gait speed, but adaptive mechanisms at the muscle cellular level are largely unknown. Methods Outpatients with poststroke hemiparesis participated in a 3‐month re...
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| Veröffentlicht in: | Muscle & nerve 2017-11, Vol.56 (5), p.954-962 |
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| creator | Andersen, Jesper L. Jørgensen, Jørgen R. Zeeman, Peter Bech‐Pedersen, Daniel T. Sørensen, Jane Ara, Ignacio Andersen, Lars L. |
| description | ABSTRACT
Introduction
Stroke is a leading cause of disability worldwide. High‐intensity physical training can improve muscle strength and gait speed, but adaptive mechanisms at the muscle cellular level are largely unknown.
Methods
Outpatients with poststroke hemiparesis participated in a 3‐month rehabilitation program combining high‐intensity strength and body‐weight supported treadmill‐training. Biopsies sampled bilaterally from vastus lateralis muscles, before, after, and at 1‐year follow‐up after intervention, were analyzed for fiber size, type, and capillarization.
Results
At baseline, paretic lower limbs had smaller muscle fiber size and lower type I and IIA and higher type IIX percentages than nonparetic lower limbs. Paretic lower limbs had increased type IIA fibers after training. At follow‐up, no difference between the lower limbs remained.
Conclusions
Although high‐intensity training appeared not to induce changes in fiber size or capillarization, increased type IIA fiber percentages may contribute to muscle power and endurance, which is crucial for functional capacity. Muscle Nerve 56: 954–962, 2017 |
| doi_str_mv | 10.1002/mus.25514 |
| format | Article |
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Introduction
Stroke is a leading cause of disability worldwide. High‐intensity physical training can improve muscle strength and gait speed, but adaptive mechanisms at the muscle cellular level are largely unknown.
Methods
Outpatients with poststroke hemiparesis participated in a 3‐month rehabilitation program combining high‐intensity strength and body‐weight supported treadmill‐training. Biopsies sampled bilaterally from vastus lateralis muscles, before, after, and at 1‐year follow‐up after intervention, were analyzed for fiber size, type, and capillarization.
Results
At baseline, paretic lower limbs had smaller muscle fiber size and lower type I and IIA and higher type IIX percentages than nonparetic lower limbs. Paretic lower limbs had increased type IIA fibers after training. At follow‐up, no difference between the lower limbs remained.
Conclusions
Although high‐intensity training appeared not to induce changes in fiber size or capillarization, increased type IIA fiber percentages may contribute to muscle power and endurance, which is crucial for functional capacity. Muscle Nerve 56: 954–962, 2017</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.25514</identifier><identifier>PMID: 27977854</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Biopsy ; capillarization ; Endurance ; Exercise Therapy - standards ; Female ; Gait ; gait rehabilitation ; Humans ; Limbs ; Male ; Middle Aged ; muscle fiber type ; Muscle Fibers, Skeletal - pathology ; Muscle Fibers, Skeletal - physiology ; Muscle Strength ; Muscles ; Paresis ; Physical Endurance - physiology ; physical therapy ; Physical training ; Rehabilitation ; strength training ; Stroke ; Stroke - pathology ; Stroke - therapy ; Stroke Rehabilitation ; Young Adult</subject><ispartof>Muscle & nerve, 2017-11, Vol.56 (5), p.954-962</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-4a24b76e1cb453ebfe2f3277a8e229e8b1dd057aab6fce475f129a438867eb303</citedby><cites>FETCH-LOGICAL-c3534-4a24b76e1cb453ebfe2f3277a8e229e8b1dd057aab6fce475f129a438867eb303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.25514$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.25514$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27977854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Jesper L.</creatorcontrib><creatorcontrib>Jørgensen, Jørgen R.</creatorcontrib><creatorcontrib>Zeeman, Peter</creatorcontrib><creatorcontrib>Bech‐Pedersen, Daniel T.</creatorcontrib><creatorcontrib>Sørensen, Jane</creatorcontrib><creatorcontrib>Ara, Ignacio</creatorcontrib><creatorcontrib>Andersen, Lars L.</creatorcontrib><title>Effects of high‐intensity physical training on muscle fiber characteristics in poststroke patients</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction
Stroke is a leading cause of disability worldwide. High‐intensity physical training can improve muscle strength and gait speed, but adaptive mechanisms at the muscle cellular level are largely unknown.
Methods
Outpatients with poststroke hemiparesis participated in a 3‐month rehabilitation program combining high‐intensity strength and body‐weight supported treadmill‐training. Biopsies sampled bilaterally from vastus lateralis muscles, before, after, and at 1‐year follow‐up after intervention, were analyzed for fiber size, type, and capillarization.
Results
At baseline, paretic lower limbs had smaller muscle fiber size and lower type I and IIA and higher type IIX percentages than nonparetic lower limbs. Paretic lower limbs had increased type IIA fibers after training. At follow‐up, no difference between the lower limbs remained.
Conclusions
Although high‐intensity training appeared not to induce changes in fiber size or capillarization, increased type IIA fiber percentages may contribute to muscle power and endurance, which is crucial for functional capacity. Muscle Nerve 56: 954–962, 2017</description><subject>Adult</subject><subject>Biopsy</subject><subject>capillarization</subject><subject>Endurance</subject><subject>Exercise Therapy - standards</subject><subject>Female</subject><subject>Gait</subject><subject>gait rehabilitation</subject><subject>Humans</subject><subject>Limbs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>muscle fiber type</subject><subject>Muscle Fibers, Skeletal - pathology</subject><subject>Muscle Fibers, Skeletal - physiology</subject><subject>Muscle Strength</subject><subject>Muscles</subject><subject>Paresis</subject><subject>Physical Endurance - physiology</subject><subject>physical therapy</subject><subject>Physical training</subject><subject>Rehabilitation</subject><subject>strength training</subject><subject>Stroke</subject><subject>Stroke - pathology</subject><subject>Stroke - therapy</subject><subject>Stroke Rehabilitation</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLFOHDEQQK0oERyEIj8QWaJJigXba6-9JUIkRCKiIEjpLK9vzJnseRePV-g6PoFvzJdkkwMKpFTTPL2ZeYR84OyIMyaO1xMeCaW4fEMWnLW6kqo1b8mCcWmqpm5_7pI9xFvGGDeN3iG7QrdaGyUXZHkWAviCdAh0FW9Wvx8eYyqQMJYNHVcbjN71tGQXU0w3dEh0XuZ7oCF2kKlfuex8gRyxRI80JjoOWLDk4RfQ0ZUIqeB78i64HuHgae6T6y9nP07Pq4vLr99OTy4qX6taVtIJ2ekGuO-kqqELIEIttHYGhGjBdHy5ZEo71zXBg9QqcNE6WZv5KehqVu-TT1vvmIe7CbDYdUQPfe8SDBNabpRojGi5ntHDV-jtMOU0X2d5qzhTXBkxU5-3lM8DYoZgxxzXLm8sZ_ZvejvXsP_Sz-zHJ-PUrWH5Qj63noHjLXAfe9j832S_X19tlX8AN72QGg</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Andersen, Jesper L.</creator><creator>Jørgensen, Jørgen R.</creator><creator>Zeeman, Peter</creator><creator>Bech‐Pedersen, Daniel T.</creator><creator>Sørensen, Jane</creator><creator>Ara, Ignacio</creator><creator>Andersen, Lars L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Effects of high‐intensity physical training on muscle fiber characteristics in poststroke patients</title><author>Andersen, Jesper L. ; Jørgensen, Jørgen R. ; Zeeman, Peter ; Bech‐Pedersen, Daniel T. ; Sørensen, Jane ; Ara, Ignacio ; Andersen, Lars L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-4a24b76e1cb453ebfe2f3277a8e229e8b1dd057aab6fce475f129a438867eb303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>capillarization</topic><topic>Endurance</topic><topic>Exercise Therapy - standards</topic><topic>Female</topic><topic>Gait</topic><topic>gait rehabilitation</topic><topic>Humans</topic><topic>Limbs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>muscle fiber type</topic><topic>Muscle Fibers, Skeletal - pathology</topic><topic>Muscle Fibers, Skeletal - physiology</topic><topic>Muscle Strength</topic><topic>Muscles</topic><topic>Paresis</topic><topic>Physical Endurance - physiology</topic><topic>physical therapy</topic><topic>Physical training</topic><topic>Rehabilitation</topic><topic>strength training</topic><topic>Stroke</topic><topic>Stroke - pathology</topic><topic>Stroke - therapy</topic><topic>Stroke Rehabilitation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Jesper L.</creatorcontrib><creatorcontrib>Jørgensen, Jørgen R.</creatorcontrib><creatorcontrib>Zeeman, Peter</creatorcontrib><creatorcontrib>Bech‐Pedersen, Daniel T.</creatorcontrib><creatorcontrib>Sørensen, Jane</creatorcontrib><creatorcontrib>Ara, Ignacio</creatorcontrib><creatorcontrib>Andersen, Lars L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Jesper L.</au><au>Jørgensen, Jørgen R.</au><au>Zeeman, Peter</au><au>Bech‐Pedersen, Daniel T.</au><au>Sørensen, Jane</au><au>Ara, Ignacio</au><au>Andersen, Lars L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of high‐intensity physical training on muscle fiber characteristics in poststroke patients</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2017-11</date><risdate>2017</risdate><volume>56</volume><issue>5</issue><spage>954</spage><epage>962</epage><pages>954-962</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction
Stroke is a leading cause of disability worldwide. High‐intensity physical training can improve muscle strength and gait speed, but adaptive mechanisms at the muscle cellular level are largely unknown.
Methods
Outpatients with poststroke hemiparesis participated in a 3‐month rehabilitation program combining high‐intensity strength and body‐weight supported treadmill‐training. Biopsies sampled bilaterally from vastus lateralis muscles, before, after, and at 1‐year follow‐up after intervention, were analyzed for fiber size, type, and capillarization.
Results
At baseline, paretic lower limbs had smaller muscle fiber size and lower type I and IIA and higher type IIX percentages than nonparetic lower limbs. Paretic lower limbs had increased type IIA fibers after training. At follow‐up, no difference between the lower limbs remained.
Conclusions
Although high‐intensity training appeared not to induce changes in fiber size or capillarization, increased type IIA fiber percentages may contribute to muscle power and endurance, which is crucial for functional capacity. Muscle Nerve 56: 954–962, 2017</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27977854</pmid><doi>10.1002/mus.25514</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Biopsy capillarization Endurance Exercise Therapy - standards Female Gait gait rehabilitation Humans Limbs Male Middle Aged muscle fiber type Muscle Fibers, Skeletal - pathology Muscle Fibers, Skeletal - physiology Muscle Strength Muscles Paresis Physical Endurance - physiology physical therapy Physical training Rehabilitation strength training Stroke Stroke - pathology Stroke - therapy Stroke Rehabilitation Young Adult |
| title | Effects of high‐intensity physical training on muscle fiber characteristics in poststroke patients |
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