Renal Function and Carotid Atherosclerosis in Adults with no Known Kidney Disease
Abstract Background and Aims A high prevalence of atherosclerotic lesions characterizes patients with chronic kidney disease, though there is little data on the relationship between kidney function and atherosclerotic changes in the healthy population or in people with no known renal impairment. The...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2017-03, Vol.27 (3), p.267-273 |
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| creator | Buscemi, Silvio Geraci, Giulio Massenti, Fatima Maria Buscemi, Carola Costa, Flavia D’Orio, Claudio Rosafio, Giuseppe Buscemi, Chiara Maniaci, Vincenza Parrinello, Gaspare |
| description | Abstract Background and Aims A high prevalence of atherosclerotic lesions characterizes patients with chronic kidney disease, though there is little data on the relationship between kidney function and atherosclerotic changes in the healthy population or in people with no known renal impairment. The aim of our study was to analyze, in a comprehensive general population with no known kidney disease, the relationship between renal function and subclinical carotid atherosclerotic damage. Methods and Results A general real-life population of 611 participants (233 males and 378 females; age ≥18 years) with no known kidney failure was selected for the study. The glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Carotid intima-media thickness (c-IMT) and plaques were assessed by duplex Doppler ultrasonography of the carotid vessels. The main laboratory and metabolic parameters were evaluated in all participants. When we divided the overall study population into tertiles according to GFR values (I tertile 99 ml/min/1.73m2 ), the c-IMT mean values and the prevalence of carotid plaques decreased with the increasing tertile of GFR. On univariate analysis, c-IMT was significantly correlated with eGFR (r = -0.33; p |
| doi_str_mv | 10.1016/j.numecd.2016.09.013 |
| format | Article |
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The aim of our study was to analyze, in a comprehensive general population with no known kidney disease, the relationship between renal function and subclinical carotid atherosclerotic damage. Methods and Results A general real-life population of 611 participants (233 males and 378 females; age ≥18 years) with no known kidney failure was selected for the study. The glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Carotid intima-media thickness (c-IMT) and plaques were assessed by duplex Doppler ultrasonography of the carotid vessels. The main laboratory and metabolic parameters were evaluated in all participants. When we divided the overall study population into tertiles according to GFR values (I tertile <85; II tertile: 85-99; III tertile >99 ml/min/1.73m2 ), the c-IMT mean values and the prevalence of carotid plaques decreased with the increasing tertile of GFR. On univariate analysis, c-IMT was significantly correlated with eGFR (r = -0.33; p<0.001), serum creatinine (r = 0.17; p<0.001), and other variables such as age, systolic blood pressure, waist circumference, fasting or random glycemia, and glycated hemoglobin (HbA1 c). On multiple regression analysis, serum creatinine was associated with c-IMT (β=0.069; p=0.017), independent of other covariates. Conclusion Our study seems to suggest the importance of early identification of people with near normal or mildly decreased renal function due to its association with carotid atherosclerosis.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2016.09.013</identifier><identifier>PMID: 27979705</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Asymptomatic Diseases ; Cardiovascular ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - physiopathology ; Carotid atherosclerosis ; Carotid Intima-Media Thickness ; Carotid plaques ; Chi-Square Distribution ; Cross-Sectional Studies ; Early Diagnosis ; Female ; Glomerular Filtration Rate ; Humans ; Italy - epidemiology ; Kidney - physiopathology ; Kidney Diseases - diagnosis ; Kidney Diseases - epidemiology ; Kidney Diseases - physiopathology ; Male ; Middle Aged ; Multivariate Analysis ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prevalence ; Prognosis ; Risk Factors ; Severity of Illness Index ; Ultrasonography, Doppler, Duplex</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2017-03, Vol.27 (3), p.267-273</ispartof><rights>The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f85714cba4368dc0d9ff8bdeb4eaac011b78a8dc616ba96ae72cb059482ed5973</citedby><cites>FETCH-LOGICAL-c417t-f85714cba4368dc0d9ff8bdeb4eaac011b78a8dc616ba96ae72cb059482ed5973</cites><orcidid>0000-0003-0730-7649</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475316301685$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27979705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buscemi, Silvio</creatorcontrib><creatorcontrib>Geraci, Giulio</creatorcontrib><creatorcontrib>Massenti, Fatima Maria</creatorcontrib><creatorcontrib>Buscemi, Carola</creatorcontrib><creatorcontrib>Costa, Flavia</creatorcontrib><creatorcontrib>D’Orio, Claudio</creatorcontrib><creatorcontrib>Rosafio, Giuseppe</creatorcontrib><creatorcontrib>Buscemi, Chiara</creatorcontrib><creatorcontrib>Maniaci, Vincenza</creatorcontrib><creatorcontrib>Parrinello, Gaspare</creatorcontrib><title>Renal Function and Carotid Atherosclerosis in Adults with no Known Kidney Disease</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and Aims A high prevalence of atherosclerotic lesions characterizes patients with chronic kidney disease, though there is little data on the relationship between kidney function and atherosclerotic changes in the healthy population or in people with no known renal impairment. The aim of our study was to analyze, in a comprehensive general population with no known kidney disease, the relationship between renal function and subclinical carotid atherosclerotic damage. Methods and Results A general real-life population of 611 participants (233 males and 378 females; age ≥18 years) with no known kidney failure was selected for the study. The glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Carotid intima-media thickness (c-IMT) and plaques were assessed by duplex Doppler ultrasonography of the carotid vessels. The main laboratory and metabolic parameters were evaluated in all participants. When we divided the overall study population into tertiles according to GFR values (I tertile <85; II tertile: 85-99; III tertile >99 ml/min/1.73m2 ), the c-IMT mean values and the prevalence of carotid plaques decreased with the increasing tertile of GFR. On univariate analysis, c-IMT was significantly correlated with eGFR (r = -0.33; p<0.001), serum creatinine (r = 0.17; p<0.001), and other variables such as age, systolic blood pressure, waist circumference, fasting or random glycemia, and glycated hemoglobin (HbA1 c). On multiple regression analysis, serum creatinine was associated with c-IMT (β=0.069; p=0.017), independent of other covariates. Conclusion Our study seems to suggest the importance of early identification of people with near normal or mildly decreased renal function due to its association with carotid atherosclerosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Asymptomatic Diseases</subject><subject>Cardiovascular</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - physiopathology</subject><subject>Carotid atherosclerosis</subject><subject>Carotid Intima-Media Thickness</subject><subject>Carotid plaques</subject><subject>Chi-Square Distribution</subject><subject>Cross-Sectional Studies</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Ultrasonography, Doppler, Duplex</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFq3DAQFSWhu0n6ByXomItdybIt6VJYNk1TEghp07OQpTGrjVdKJbth_74ym-aQSxCMGObNG957CH2mpKSEtl-2pZ92YGxZ5a4ksiSUfUBL2khSMF7JI7Qkksmi5g1boJOUtoQwTlj9ES0qLvMjzRLd_wSvB3w1eTO64LH2Fq91DKOzeDVuIIZkhrm6hJ3HKzsNY8LPbtxgH_CND88e3zjrYY8vXQKd4Awd93pI8OnlP0W_r749rK-L27vvP9ar28LUlI9FLxpOa9PpmrXCGmJl34vOQleD1oZQ2nGh86Clbadlq4FXpiONrEUFtpGcnaKLA-9TDH8mSKPauWRgGLSHMCVFRVO1grZSZGh9gJosJEXo1VN0Ox33ihI1m6m26mCmms1URKpsZl47f7kwdTuwr0v_3cuArwcAZJ1_HUSVjANvwLoIZlQ2uPcuvCUwg_PO6OER9pC2YYo5naxFpUoR9WsOdM6TtiyziIb9A7G1nPA</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Buscemi, Silvio</creator><creator>Geraci, Giulio</creator><creator>Massenti, Fatima Maria</creator><creator>Buscemi, Carola</creator><creator>Costa, Flavia</creator><creator>D’Orio, Claudio</creator><creator>Rosafio, Giuseppe</creator><creator>Buscemi, Chiara</creator><creator>Maniaci, Vincenza</creator><creator>Parrinello, Gaspare</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0730-7649</orcidid></search><sort><creationdate>20170301</creationdate><title>Renal Function and Carotid Atherosclerosis in Adults with no Known Kidney Disease</title><author>Buscemi, Silvio ; Geraci, Giulio ; Massenti, Fatima Maria ; Buscemi, Carola ; Costa, Flavia ; D’Orio, Claudio ; Rosafio, Giuseppe ; Buscemi, Chiara ; Maniaci, Vincenza ; Parrinello, Gaspare</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f85714cba4368dc0d9ff8bdeb4eaac011b78a8dc616ba96ae72cb059482ed5973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asymptomatic Diseases</topic><topic>Cardiovascular</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - physiopathology</topic><topic>Carotid atherosclerosis</topic><topic>Carotid Intima-Media Thickness</topic><topic>Carotid plaques</topic><topic>Chi-Square Distribution</topic><topic>Cross-Sectional Studies</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Ultrasonography, Doppler, Duplex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buscemi, Silvio</creatorcontrib><creatorcontrib>Geraci, Giulio</creatorcontrib><creatorcontrib>Massenti, Fatima Maria</creatorcontrib><creatorcontrib>Buscemi, Carola</creatorcontrib><creatorcontrib>Costa, Flavia</creatorcontrib><creatorcontrib>D’Orio, Claudio</creatorcontrib><creatorcontrib>Rosafio, Giuseppe</creatorcontrib><creatorcontrib>Buscemi, Chiara</creatorcontrib><creatorcontrib>Maniaci, Vincenza</creatorcontrib><creatorcontrib>Parrinello, Gaspare</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buscemi, Silvio</au><au>Geraci, Giulio</au><au>Massenti, Fatima Maria</au><au>Buscemi, Carola</au><au>Costa, Flavia</au><au>D’Orio, Claudio</au><au>Rosafio, Giuseppe</au><au>Buscemi, Chiara</au><au>Maniaci, Vincenza</au><au>Parrinello, Gaspare</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Function and Carotid Atherosclerosis in Adults with no Known Kidney Disease</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>27</volume><issue>3</issue><spage>267</spage><epage>273</epage><pages>267-273</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and Aims A high prevalence of atherosclerotic lesions characterizes patients with chronic kidney disease, though there is little data on the relationship between kidney function and atherosclerotic changes in the healthy population or in people with no known renal impairment. The aim of our study was to analyze, in a comprehensive general population with no known kidney disease, the relationship between renal function and subclinical carotid atherosclerotic damage. Methods and Results A general real-life population of 611 participants (233 males and 378 females; age ≥18 years) with no known kidney failure was selected for the study. The glomerular filtration rate (GFR) was estimated according to the CKD-EPI equation. Carotid intima-media thickness (c-IMT) and plaques were assessed by duplex Doppler ultrasonography of the carotid vessels. The main laboratory and metabolic parameters were evaluated in all participants. When we divided the overall study population into tertiles according to GFR values (I tertile <85; II tertile: 85-99; III tertile >99 ml/min/1.73m2 ), the c-IMT mean values and the prevalence of carotid plaques decreased with the increasing tertile of GFR. On univariate analysis, c-IMT was significantly correlated with eGFR (r = -0.33; p<0.001), serum creatinine (r = 0.17; p<0.001), and other variables such as age, systolic blood pressure, waist circumference, fasting or random glycemia, and glycated hemoglobin (HbA1 c). On multiple regression analysis, serum creatinine was associated with c-IMT (β=0.069; p=0.017), independent of other covariates. Conclusion Our study seems to suggest the importance of early identification of people with near normal or mildly decreased renal function due to its association with carotid atherosclerosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27979705</pmid><doi>10.1016/j.numecd.2016.09.013</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0730-7649</orcidid></addata></record> |
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| subjects | Adult Aged Asymptomatic Diseases Cardiovascular Carotid Arteries - diagnostic imaging Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Artery Diseases - physiopathology Carotid atherosclerosis Carotid Intima-Media Thickness Carotid plaques Chi-Square Distribution Cross-Sectional Studies Early Diagnosis Female Glomerular Filtration Rate Humans Italy - epidemiology Kidney - physiopathology Kidney Diseases - diagnosis Kidney Diseases - epidemiology Kidney Diseases - physiopathology Male Middle Aged Multivariate Analysis Plaque, Atherosclerotic Predictive Value of Tests Prevalence Prognosis Risk Factors Severity of Illness Index Ultrasonography, Doppler, Duplex |
| title | Renal Function and Carotid Atherosclerosis in Adults with no Known Kidney Disease |
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