Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells

Matrix metalloproteinase enzymes (MMPs) play important role in inflammation, malignant cell proliferation, invasion and angiogenesis by mediating extracellular matrix degradation. Doxycycline, a synthetic tetracycline, behaves as a MMP inhibitor at a subantimicrobial dose and inhibits tumor cell pro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Folia histochemica et cytobiologica 2016-01, Vol.54 (4), p.171-180
Hauptverfasser:	Ogut, Deniz, Reel, Buket, Gonen Korkmaz, Ceren, Arun, Mehmet Zuhuri, Cilaker Micili, Serap, Ergur, Bekir Ugur
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antibiotics Cell growth Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Down-Regulation - drug effects Doxycycline Doxycycline - pharmacology Enzyme Activation Extracellular matrix Gelatin Gelatinase A Gelatinase B Gelatinases - metabolism Humans I-kappa B Kinase - metabolism IKK protein Immunohistochemistry Kinases Lipopolysaccharides Lipopolysaccharides - pharmacology Male Matrix metalloproteinase Matrix metalloproteinases Matrix Metalloproteinases - biosynthesis Metalloproteinase Neoplasm Invasiveness Neutrophil collagenase NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism NF-κB protein Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteinase Signal Transduction - drug effects Signaling Stromelysin 2 Transcription Factor RelA - metabolism Tumors Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!