Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice

Sepsis survivors frequently develop late cognitive impairment. Because little is known on the mechanisms of post-septic memory deficits, there are no current effective approaches to prevent or treat such symptoms. Here, we subjected mice to severe sepsis induced by cecal ligation and puncture (CLP)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular neurobiology 2018-01, Vol.55 (1), p.435-444
Hauptverfasser:	Neves, Fernanda S., Marques, Patrícia T., Barros‑Aragão, Fernanda, Nunes, José Bruno, Venancio, Aline M., Cozachenco, Danielle, Frozza, Rudimar L., Passos, Giselle F., Costa, Robson, de Oliveira, Jade, Engel, Daiane F., De Bem, Andreza F., Benjamim, Claudia F., De Felice, Fernanda G., Ferreira, Sergio T., Clarke, Julia R., Figueiredo, Claudia P.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Biomedical and Life Sciences Biomedicine Brain - metabolism Brain - pathology Cecum Cell Biology Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Cyclic AMP response element-binding protein Exploratory Behavior - physiology GLP-1 receptor agonists Hippocampal plasticity Hippocampus Insulin Insulin - metabolism Insulin receptor substrate 1 Male Memory Mice Neurobiology Neurology Neurosciences Pattern recognition Phosphorylation Sepsis Sepsis - complications Sepsis - metabolism Sepsis - pathology Serine Signal Transduction - physiology Surgery Synaptic plasticity Synaptophysin Tumor necrosis factor-TNF Tumor necrosis factor-α Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!