Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

Although the physiologic role of muscarinic receptors in bladder function and the therapeutic efficacy of muscarinic antagonists for the treatment of overactive bladder are well established, the role of β3-adrenergic receptors (β3ARs) and their potential as therapeutics is just emerging. In this man...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-02, Vol.360 (2), p.346-355
Hauptverfasser:	Di Salvo, J., Nagabukuro, H., Wickham, L.A., Abbadie, C., DeMartino, J.A., Fitzmaurice, A., Gichuru, L., Kulick, A., Donnelly, M.J., Jochnowitz, N., Hurley, A.L., Pereira, A., Sanfiz, A., Veronin, G., Villa, K., Woods, J., Zamlynny, B., Zycband, E., Salituro, G.M., Frenkl, T., Weber, A.E., Edmondson, S.D., Struthers, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-3 Receptor Agonists - pharmacology Adrenergic beta-3 Receptor Agonists - therapeutic use Animals Drug Interactions Female Humans Macaca mulatta Male Muscarinic Antagonists - pharmacology Muscarinic Antagonists - therapeutic use Muscle, Smooth - drug effects Muscle, Smooth - physiopathology Protein Transport - drug effects Pyrimidinones - pharmacology Pyrimidinones - therapeutic use Pyrrolidines - pharmacology Pyrrolidines - therapeutic use Rats Receptors, Adrenergic, beta-3 - metabolism Species Specificity Urinary Bladder - drug effects Urinary Bladder - physiopathology Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - metabolism Urinary Bladder, Overactive - physiopathology Urodynamics - drug effects
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