Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

Preventing HIV-1 infection, especially with female-controlled approaches, is a high priority. In this trial in South Africa and Uganda, a dapivirine vaginal ring was associated with a rate of acquisition of HIV-1 infection that was approximately 30% lower than that with placebo. In 2014, approximate...

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Veröffentlicht in:	The New England journal of medicine 2016-12, Vol.375 (22), p.2133-2143
Hauptverfasser:	Nel, Annalene, van Niekerk, Neliëtte, Kapiga, Saidi, Bekker, Linda-Gail, Gama, Cynthia, Gill, Katherine, Kamali, Anatoli, Kotze, Philip, Louw, Cheryl, Mabude, Zonke, Miti, Nokuthula, Kusemererwa, Sylvia, Tempelman, Hugo, Carstens, Hannelie, Devlin, Brid, Isaacs, Michelle, Malherbe, Mariëtte, Mans, Winel, Nuttall, Jeremy, Russell, Marisa, Ntshele, Smangaliso, Smit, Marlie, Solai, Leonard, Spence, Patrick, Steytler, John, Windle, Kathleen, Borremans, Maarten, Resseler, Sophie, Van Roey, Jens, Parys, Wim, Vangeneugden, Tony, Van Baelen, Ben, Rosenberg, Zeda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Antiretroviral drugs Disease prevention Double-Blind Method Drug Resistance, Viral Female HIV HIV Infections - epidemiology HIV Infections - prevention & control HIV Seropositivity HIV-1 - isolation & purification Human immunodeficiency virus Humans Incidence Microbicides Middle Aged Patient safety Pregnancy Pyrimidines - administration & dosage Pyrimidines - adverse effects Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects RNA, Viral - blood Safety Seroconversion South Africa - epidemiology Uganda - epidemiology Vagina Viral infections Women Young Adult
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