Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia
Objectives: Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate is only 20-40%. One of the main obstacles to treatment succe...
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| Veröffentlicht in: | Hematology (Luxembourg) 2017-05, Vol.22 (5), p.286-291 |
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| creator | Olarte Carrillo, I. Ramos Peñafiel, C. Miranda Peralta, E. Rozen Fuller, E. Kassack Ipiña, J. J. Centeno Cruz, F. Garrido Guerrero, E. Collazo Jaloma, J. Nacho Vargas, K. Martínez Tovar, A. |
| description | Objectives: Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate is only 20-40%. One of the main obstacles to treatment success is the drug resistance of leukemic cells. Therefore, our research group analyzed the ABCB1 and ABCG2 gene expression levels in 61 patients diagnosed with ALL and assessed whether the levels affected the clinical parameters and 40-month survival rate.
Methods: The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls. The association between ABCB1 and ABCG2 gene expression levels and clinical variables was determined using the Chi-square test and Fisher's exact test. Overall survival (OS) was determined using the Kaplan-Meier method.
Results: The results showed high ABCB1 and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively. A total of 52% of the study patients expressed high ABCB1 levels and were significantly associated with the high-risk patient group and a decreased 40-month survival rate of 78%. Only 49% of the patients expressed high ABCG2 gene levels. No association was found between the clinical parameters and the ABCG2 gene expression levels.
Conclusions: Early detection of ABCB1 gene expression levels could be important for the diagnosis and monitoring of ALL patients. |
| doi_str_mv | 10.1080/10245332.2016.1265780 |
| format | Article |
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Methods: The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls. The association between ABCB1 and ABCG2 gene expression levels and clinical variables was determined using the Chi-square test and Fisher's exact test. Overall survival (OS) was determined using the Kaplan-Meier method.
Results: The results showed high ABCB1 and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively. A total of 52% of the study patients expressed high ABCB1 levels and were significantly associated with the high-risk patient group and a decreased 40-month survival rate of 78%. Only 49% of the patients expressed high ABCG2 gene levels. No association was found between the clinical parameters and the ABCG2 gene expression levels.
Conclusions: Early detection of ABCB1 gene expression levels could be important for the diagnosis and monitoring of ALL patients.</description><identifier>ISSN: 1607-8454</identifier><identifier>EISSN: 1607-8454</identifier><identifier>DOI: 10.1080/10245332.2016.1265780</identifier><identifier>PMID: 27960630</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>ABCB1 ; ABCG2 ; acute lymphoblastic leukemia ; Adolescent ; Adult ; ATP Binding Cassette Transporter, Sub-Family B - biosynthesis ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Survival Rate</subject><ispartof>Hematology (Luxembourg), 2017-05, Vol.22 (5), p.286-291</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-809026fc37afdebe9803b2f75451d9ef07fe5bc462d8f824b7df8431df71e58d3</citedby><cites>FETCH-LOGICAL-c479t-809026fc37afdebe9803b2f75451d9ef07fe5bc462d8f824b7df8431df71e58d3</cites><orcidid>0000-0003-0957-9090 ; 0000-0001-9261-7451 ; 0000-0003-3165-7286 ; 0000-0002-3512-4519 ; 0000-0002-5912-8346 ; 0000-0001-5834-1551 ; 0000-0003-4447-3793 ; 0000-0003-0496-3122 ; 0000-0002-5374-0534 ; 0000-0002-5713-3731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27960630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olarte Carrillo, I.</creatorcontrib><creatorcontrib>Ramos Peñafiel, C.</creatorcontrib><creatorcontrib>Miranda Peralta, E.</creatorcontrib><creatorcontrib>Rozen Fuller, E.</creatorcontrib><creatorcontrib>Kassack Ipiña, J. J.</creatorcontrib><creatorcontrib>Centeno Cruz, F.</creatorcontrib><creatorcontrib>Garrido Guerrero, E.</creatorcontrib><creatorcontrib>Collazo Jaloma, J.</creatorcontrib><creatorcontrib>Nacho Vargas, K.</creatorcontrib><creatorcontrib>Martínez Tovar, A.</creatorcontrib><title>Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia</title><title>Hematology (Luxembourg)</title><addtitle>Hematology</addtitle><description>Objectives: Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate is only 20-40%. One of the main obstacles to treatment success is the drug resistance of leukemic cells. Therefore, our research group analyzed the ABCB1 and ABCG2 gene expression levels in 61 patients diagnosed with ALL and assessed whether the levels affected the clinical parameters and 40-month survival rate.
Methods: The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls. The association between ABCB1 and ABCG2 gene expression levels and clinical variables was determined using the Chi-square test and Fisher's exact test. Overall survival (OS) was determined using the Kaplan-Meier method.
Results: The results showed high ABCB1 and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively. A total of 52% of the study patients expressed high ABCB1 levels and were significantly associated with the high-risk patient group and a decreased 40-month survival rate of 78%. Only 49% of the patients expressed high ABCG2 gene levels. No association was found between the clinical parameters and the ABCG2 gene expression levels.
Conclusions: Early detection of ABCB1 gene expression levels could be important for the diagnosis and monitoring of ALL patients.</description><subject>ABCB1</subject><subject>ABCG2</subject><subject>acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>ATP Binding Cassette Transporter, Sub-Family B - biosynthesis</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Survival Rate</subject><issn>1607-8454</issn><issn>1607-8454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERT_gJ4B85LLL2Ilj50a7ogWpUi_t2XLscWtw7MVOCvvvyWq3iBOneaV53hnpIeQ9gzUDBZ8Y8FY0DV9zYN2a8U5IBa_IGetArlQr2tf_5FNyXut3AM5BwhtyymXfQdfAGbGbGFKwJtIaHlPwS0wWafZ0ekJ6ebW5YtQkt083nD5iQoq_twVrDTnRiM8YKw2JGjtPSONu3D7lIZo6Bbts5x84BvOWnHgTK747zgvycP3lfvN1dXt3821zebuyreynlYIeeOdtI413OGCvoBm4l6IVzPXoQXoUg2077pRXvB2k86ptmPOSoVCuuSAfD3e3Jf-csU56DNVijCZhnqtmSvBOMgWwoOKA2pJrLej1toTRlJ1moPd-9Ytfvferj36X3ofji3kY0f1tvQhdgM8HICSfy2h-5RKdnswu5uLL4jZU3fz_xx_u-olY</recordid><startdate>20170528</startdate><enddate>20170528</enddate><creator>Olarte Carrillo, I.</creator><creator>Ramos Peñafiel, C.</creator><creator>Miranda Peralta, E.</creator><creator>Rozen Fuller, E.</creator><creator>Kassack Ipiña, J. J.</creator><creator>Centeno Cruz, F.</creator><creator>Garrido Guerrero, E.</creator><creator>Collazo Jaloma, J.</creator><creator>Nacho Vargas, K.</creator><creator>Martínez Tovar, A.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0957-9090</orcidid><orcidid>https://orcid.org/0000-0001-9261-7451</orcidid><orcidid>https://orcid.org/0000-0003-3165-7286</orcidid><orcidid>https://orcid.org/0000-0002-3512-4519</orcidid><orcidid>https://orcid.org/0000-0002-5912-8346</orcidid><orcidid>https://orcid.org/0000-0001-5834-1551</orcidid><orcidid>https://orcid.org/0000-0003-4447-3793</orcidid><orcidid>https://orcid.org/0000-0003-0496-3122</orcidid><orcidid>https://orcid.org/0000-0002-5374-0534</orcidid><orcidid>https://orcid.org/0000-0002-5713-3731</orcidid></search><sort><creationdate>20170528</creationdate><title>Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia</title><author>Olarte Carrillo, I. ; Ramos Peñafiel, C. ; Miranda Peralta, E. ; Rozen Fuller, E. ; Kassack Ipiña, J. J. ; Centeno Cruz, F. ; Garrido Guerrero, E. ; Collazo Jaloma, J. ; Nacho Vargas, K. ; Martínez Tovar, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-809026fc37afdebe9803b2f75451d9ef07fe5bc462d8f824b7df8431df71e58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>ABCB1</topic><topic>ABCG2</topic><topic>acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>ATP Binding Cassette Transporter, Sub-Family B - biosynthesis</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olarte Carrillo, I.</creatorcontrib><creatorcontrib>Ramos Peñafiel, C.</creatorcontrib><creatorcontrib>Miranda Peralta, E.</creatorcontrib><creatorcontrib>Rozen Fuller, E.</creatorcontrib><creatorcontrib>Kassack Ipiña, J. J.</creatorcontrib><creatorcontrib>Centeno Cruz, F.</creatorcontrib><creatorcontrib>Garrido Guerrero, E.</creatorcontrib><creatorcontrib>Collazo Jaloma, J.</creatorcontrib><creatorcontrib>Nacho Vargas, K.</creatorcontrib><creatorcontrib>Martínez Tovar, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hematology (Luxembourg)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olarte Carrillo, I.</au><au>Ramos Peñafiel, C.</au><au>Miranda Peralta, E.</au><au>Rozen Fuller, E.</au><au>Kassack Ipiña, J. J.</au><au>Centeno Cruz, F.</au><au>Garrido Guerrero, E.</au><au>Collazo Jaloma, J.</au><au>Nacho Vargas, K.</au><au>Martínez Tovar, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia</atitle><jtitle>Hematology (Luxembourg)</jtitle><addtitle>Hematology</addtitle><date>2017-05-28</date><risdate>2017</risdate><volume>22</volume><issue>5</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>1607-8454</issn><eissn>1607-8454</eissn><abstract>Objectives: Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate is only 20-40%. One of the main obstacles to treatment success is the drug resistance of leukemic cells. Therefore, our research group analyzed the ABCB1 and ABCG2 gene expression levels in 61 patients diagnosed with ALL and assessed whether the levels affected the clinical parameters and 40-month survival rate.
Methods: The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls. The association between ABCB1 and ABCG2 gene expression levels and clinical variables was determined using the Chi-square test and Fisher's exact test. Overall survival (OS) was determined using the Kaplan-Meier method.
Results: The results showed high ABCB1 and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively. A total of 52% of the study patients expressed high ABCB1 levels and were significantly associated with the high-risk patient group and a decreased 40-month survival rate of 78%. Only 49% of the patients expressed high ABCG2 gene levels. No association was found between the clinical parameters and the ABCG2 gene expression levels.
Conclusions: Early detection of ABCB1 gene expression levels could be important for the diagnosis and monitoring of ALL patients.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27960630</pmid><doi>10.1080/10245332.2016.1265780</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0957-9090</orcidid><orcidid>https://orcid.org/0000-0001-9261-7451</orcidid><orcidid>https://orcid.org/0000-0003-3165-7286</orcidid><orcidid>https://orcid.org/0000-0002-3512-4519</orcidid><orcidid>https://orcid.org/0000-0002-5912-8346</orcidid><orcidid>https://orcid.org/0000-0001-5834-1551</orcidid><orcidid>https://orcid.org/0000-0003-4447-3793</orcidid><orcidid>https://orcid.org/0000-0003-0496-3122</orcidid><orcidid>https://orcid.org/0000-0002-5374-0534</orcidid><orcidid>https://orcid.org/0000-0002-5713-3731</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | ABCB1 ABCG2 acute lymphoblastic leukemia Adolescent Adult ATP Binding Cassette Transporter, Sub-Family B - biosynthesis ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Proteins - biosynthesis Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Survival Rate |
| title | Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia |
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