Inhibition of casein kinase 2 prevents growth of human osteosarcoma

High-dose chemotherapy and surgical treatment have improved the prognosis of osteosarcoma. However, more than 20% of patients with osteosarcoma still have a poor prognosis. We investigated the expression and function of casein kinase 2 (CK2) in osteosarcoma growth. We then examined the effects of CX...

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Veröffentlicht in:	Oncology reports 2017-02, Vol.37 (2), p.1141-1147
Hauptverfasser:	Takahashi, Kengo, Setoguchi, Takao, Tsuru, Arisa, Saitoh, Yoshinobu, Nagano, Satoshi, Ishidou, Yasuhiro, Maeda, Shingo, Furukawa, Tatsuhiko, Komiya, Setsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Arsenic Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - enzymology Bone Neoplasms - pathology Breast cancer Cancer therapies Care and treatment casein kinase 2 Casein Kinase II - antagonists & inhibitors Casein Kinase II - genetics Casein Kinase II - metabolism Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Clinical trials Development and progression Drug dosages Enzymes Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Genetic aspects Health aspects Humans Kinases Laboratory animals Lung cancer Medical prognosis Medical research Metastasis Mice Naphthyridines - pharmacology Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - enzymology Osteosarcoma - pathology Phosphotransferases Proteins Regulation RNA, Small Interfering - genetics Sarcoma Stem cells Studies Tumors Xenograft Model Antitumor Assays
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