Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival

Having found previously that leukemic cells with multidrug resistant (MDR) phenotype, but not their sensitive counterparts, exhibit collateral sensitivity to cold stress in a P-gp-dependent manner, our aim was to study the signaling pathways involved in this phenomenon in sensitive (L1210) and resis...

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Veröffentlicht in:	Cellular signalling 2017-01, Vol.30, p.162-170
Hauptverfasser:	Cerezo, David, Ruiz-Alcaraz, Antonio J., Lencina-Guardiola, Miriam, Cánovas, Manuel, García-Peñarrubia, Pilar, Martínez-López, Inmaculada, Martín-Orozco, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cell Line, Tumor Cell Survival - drug effects Cold Temperature Cold-stress Collateral sensitivity Drug Resistance, Multiple Drug Resistance, Neoplasm Extracellular Signal-Regulated MAP Kinases - metabolism Humans JNK Mitogen-Activated Protein Kinases - metabolism Leukemia - enzymology Leukemia - pathology Leukemic cells MAP Kinase Signaling System - drug effects MAPK MDR Mice Models, Biological P-glycoprotein Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Transfection
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