Presence of negative supercoiling in aggregates of histone H1-plasmidic polynucleosome complexes

[Display omitted] It was shown in the past that in the presence of histone H1, plasmidic polynucleosomes formed densely packed aggregates. Our current studies demonstrate that these aggregates are susceptible to the actions of E. coli topoisomerase I, human topoisomerase I and DNA nicking enzyme, wh...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-01, Vol.27 (2), p.168-170
Hauptverfasser:	Zhang, Hao, Li, Tianhu
Format:	Artikel
Sprache:	eng
Schlagworte:	AFM Deoxyribonuclease I - chemistry DNA Topoisomerases, Type I - chemistry DNA, Superhelical - chemistry E. coli topo I Escherichia coli Histone H1 Histones - chemistry Humans Nucleosomes - chemistry Plasmid DNA Plasmids Polynucleosome
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