Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition

[Display omitted] The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol...

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Veröffentlicht in:	International journal of pharmaceutics 2017-01, Vol.517 (1-2), p.256-268
Hauptverfasser:	Kassem, Ahmed Alaa, Abd El-Alim, Sameh Hosam, Asfour, Marwa Hasanein
Format:	Artikel
Sprache:	eng
Schlagworte:	8-methoxypsoralen Animals Confocal laser scanning microscopy Drug Carriers - chemistry Drug Delivery Systems Drug Liberation Drug Stability Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogen-Ion Concentration Liposomes - administration & dosage Liposomes - chemistry Liposomes - pharmacokinetics Liposomes - ultrastructure Male Methoxsalen - administration & dosage Methoxsalen - chemistry Methoxsalen - pharmacokinetics Niosomes Particle Size Rats Rheology Skin Absorption Skin permeation Topical delivery
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