Tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus
Japanese encephalitis virus （jEV） is a mosquito-borne virus of the family Flaviviridae. It is the causative agent of Japanese encephalitis with approximately 50,000 infection cases and 10,000 fatal cases annually in Asia （Erlanger et al., 2009）. Although liveattenuated JEV vaccine has been developed...
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| Veröffentlicht in: | Journal of genetics and genomics 2016-12, Vol.43 (12), p.709-712 |
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| container_title | Journal of genetics and genomics |
| container_volume | 43 |
| creator | Deng, Xufang Wei, Jianchao Shi, Zixue Yan, Wenjun Wu, Zhuanchang Shao, Donghua Li, Beibei Liu, Ke Wang, Xiaodu Qiu, Yafeng Ma, Zhiyong |
| description | Japanese encephalitis virus （jEV） is a mosquito-borne virus of the family Flaviviridae. It is the causative agent of Japanese encephalitis with approximately 50,000 infection cases and 10,000 fatal cases annually in Asia （Erlanger et al., 2009）. Although liveattenuated JEV vaccine has been developed and used for human and pig vaccination, JE occurs epidemically or sporadically in some developing countries or even in vaccinated areas （Solomon, 2006）. Host resistance factors play an important role in the outcome of viral infection. |
| doi_str_mv | 10.1016/j.jgg.2016.07.002 |
| format | Article |
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It is the causative agent of Japanese encephalitis with approximately 50,000 infection cases and 10,000 fatal cases annually in Asia （Erlanger et al., 2009）. Although liveattenuated JEV vaccine has been developed and used for human and pig vaccination, JE occurs epidemically or sporadically in some developing countries or even in vaccinated areas （Solomon, 2006）. 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| subjects | A549 Cells Animals Antiviral Agents - metabolism Encephalitis Virus, Japanese Encephalitis, Japanese - prevention & control Encephalitis, Japanese - virology Humans Mice p53 Tumor Suppressor Protein p53 - metabolism 乙型脑炎病毒 乙脑疫苗 抑癌基因 接种疫苗 日本脑炎病毒 流行性乙型脑炎 病毒分子 |
| title | Tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus |
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