Development and validation of a simple and robust HPLC method with UV detection for quantification of the hepatitis C virus inhibitor daclatasvir in human plasma

[Display omitted] •The first HPLC-UV method was developed for the determination of DCV in human plasma.•This method was applied to quantification of daclatasvir in clinical samples.•Daclatasvir is degraded by sunlight. Daclatasvir is an inhibitor of hepatitis C virus NS5A protein that is used for th...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-02, Vol.134, p.275-281
Hauptverfasser:	Nannetti, Giulio, Messa, Lorenzo, Celegato, Marta, Pagni, Silvana, Basso, Monica, Parisi, Saverio G., Palù, Giorgio, Loregian, Arianna
Format:	Artikel
Sprache:	eng
Schlagworte:	BMS-790052 Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Chromatography, Reverse-Phase - methods Chromatography, Reverse-Phase - standards Daclatasvir Drug Storage - methods Drug Storage - standards HCV NS5A inhibitor Hepacivirus - drug effects Hepacivirus - metabolism HPLC-UV Humans Imidazoles - blood Imidazoles - pharmacology Reproducibility of Results Solid-phase extraction Therapeutic drug monitoring Ultraviolet Rays
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