Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens

Highlights • SAM vaccines were engineered to express prototype bacterial antigens from GAS and GBS. • Mice immunized with both vaccines produced fully functional serum antibodies. • Antibodies elicited by SAM vaccines conferred protection in mouse infection models. • SAM vaccines have the potential...

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Veröffentlicht in:	Vaccine 2017-01, Vol.35 (2), p.361-368
Hauptverfasser:	Maruggi, Giulietta, Chiarot, Emiliano, Giovani, Cinzia, Buccato, Scilla, Bonacci, Stefano, Frigimelica, Elisabetta, Margarit, Immaculada, Geall, Andrew, Bensi, Giuliano, Maione, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Bacterial - blood Antigens Antigens, Bacterial - biosynthesis Antigens, Bacterial - genetics Antigens, Bacterial - immunology Deoxyribonucleic acid Disease Models, Animal DNA Female GAS Genes Genomes Immune response Immunization Immunogenicity Immunoglobulins Manufacturing industry Mice Nucleic acids Pathogens Protective immunity Proteins RNA polymerase RNA, Messenger - biosynthesis RNA, Messenger - genetics SAM GBS Self-amplifying mRNA Streptococcal Infections - prevention & control Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus agalactiae - genetics Streptococcus agalactiae - immunology Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Vaccine Vaccines Vectors (Biology)
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Beschreibung
Zusammenfassung:	Highlights • SAM vaccines were engineered to express prototype bacterial antigens from GAS and GBS. • Mice immunized with both vaccines produced fully functional serum antibodies. • Antibodies elicited by SAM vaccines conferred protection in mouse infection models. • SAM vaccines have the potential to be used for a broad range of targets.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.11.040