Probing the Binding Interfaces of Histone-Aptamer by Photo Cross-Linking Mass Spectrometry

Histone proteins, which could interact with DNA, play important roles in the regulation of chromatin structures, transcription, and other DNA-based biological processes. Here, we developed a novel aptamer-based probe for the analysis of histone H4-aptamer interfaces. This probe contains a DNA sequen...

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Veröffentlicht in:	ACS chemical biology 2017-01, Vol.12 (1), p.57-62
Hauptverfasser:	Lu, Congcong, Tian, Shanshan, Zhai, Guijin, Yuan, Zuofei, Li, Yijun, He, Xiwen, Zhang, Yukui, Zhang, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - metabolism Binding Sites Biotinylation Cross-Linking Reagents - chemistry Cross-Linking Reagents - metabolism Disulfides - chemistry Disulfides - metabolism Histones - chemistry Histones - metabolism Humans Light Mass Spectrometry
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