Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum
The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67...
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| Veröffentlicht in: | Journal of biological regulators and homeostatic agents 2016-07, Vol.30 (3), p.773-776 |
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| description | The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1, VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significant differences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between the two groups (P less than0.05). The Spearmans Rank-Order Correlation analysis indicated that the expressions of NDRG1 protein and VEGF protein were positively correlated by the Spearmans Rank-Order Correlation analysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA. |
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Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1, VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significant differences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between the two groups (P less than0.05). The Spearmans Rank-Order Correlation analysis indicated that the expressions of NDRG1 protein and VEGF protein were positively correlated by the Spearmans Rank-Order Correlation analysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA.</description><identifier>ISSN: 0393-974X</identifier><identifier>PMID: 27655496</identifier><language>eng</language><publisher>Italy</publisher><subject>Adolescent ; Adult ; Cell Cycle Proteins - biosynthesis ; Cell Cycle Proteins - genetics ; Cell Division ; Condylomata Acuminata - genetics ; Condylomata Acuminata - metabolism ; Condylomata Acuminata - pathology ; Female ; Gene Expression Regulation ; Genital Diseases, Female - genetics ; Genital Diseases, Female - metabolism ; Genital Diseases, Female - pathology ; Genital Diseases, Male - genetics ; Genital Diseases, Male - metabolism ; Genital Diseases, Male - pathology ; Humans ; Intracellular Signaling Peptides and Proteins - biosynthesis ; Intracellular Signaling Peptides and Proteins - genetics ; Ki-67 Antigen - biosynthesis ; Ki-67 Antigen - genetics ; Male ; Middle Aged ; Vascular Endothelial Growth Factor A - biosynthesis ; Vascular Endothelial Growth Factor A - genetics ; Young Adult</subject><ispartof>Journal of biological regulators and homeostatic agents, 2016-07, Vol.30 (3), p.773-776</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27655496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, G W</creatorcontrib><creatorcontrib>Guo, Y</creatorcontrib><creatorcontrib>Jin, B</creatorcontrib><title>Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum</title><title>Journal of biological regulators and homeostatic agents</title><addtitle>J Biol Regul Homeost Agents</addtitle><description>The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1, VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significant differences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between the two groups (P less than0.05). The Spearmans Rank-Order Correlation analysis indicated that the expressions of NDRG1 protein and VEGF protein were positively correlated by the Spearmans Rank-Order Correlation analysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Division</subject><subject>Condylomata Acuminata - genetics</subject><subject>Condylomata Acuminata - metabolism</subject><subject>Condylomata Acuminata - pathology</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Genital Diseases, Female - genetics</subject><subject>Genital Diseases, Female - metabolism</subject><subject>Genital Diseases, Female - pathology</subject><subject>Genital Diseases, Male - genetics</subject><subject>Genital Diseases, Male - metabolism</subject><subject>Genital Diseases, Male - pathology</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Ki-67 Antigen - biosynthesis</subject><subject>Ki-67 Antigen - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Young Adult</subject><issn>0393-974X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j09LwzAcQHNQ3Jx-BcnRg4X8TwNeRt2qOBRExVv5rU0g0iS1acF9ewXn6V0eD94JWhJueGG0-Fig85w_CRFcaH2GFkwrKYVRS3S7-R5Gm7NPMePk8NPdS01v8Pum3mKIHX70hdLYR1yl2B36FACv2zn4CNMcLtCpgz7byyNX6G27ea3ui91z_VCtd8XAKJ0KywjojhGq1F5IqQQlWhHtWmDSWUFVCZqW0BLDDAcghkpXylI4akhnrOUrdP3XHcb0Nds8NcHn1vY9RJvm3NBSMiU1Z_RXvTqq8z7YrhlGH2A8NP_H_Ad7sE1m</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Yin, G W</creator><creator>Guo, Y</creator><creator>Jin, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum</title><author>Yin, G W ; Guo, Y ; Jin, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-e20a7d20166b45564107607fca25fe4168a718ac09293aa0915f8584f190d9ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Division</topic><topic>Condylomata Acuminata - genetics</topic><topic>Condylomata Acuminata - metabolism</topic><topic>Condylomata Acuminata - pathology</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Genital Diseases, Female - genetics</topic><topic>Genital Diseases, Female - metabolism</topic><topic>Genital Diseases, Female - pathology</topic><topic>Genital Diseases, Male - genetics</topic><topic>Genital Diseases, Male - metabolism</topic><topic>Genital Diseases, Male - pathology</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Ki-67 Antigen - biosynthesis</topic><topic>Ki-67 Antigen - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, G W</creatorcontrib><creatorcontrib>Guo, Y</creatorcontrib><creatorcontrib>Jin, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biological regulators and homeostatic agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, G W</au><au>Guo, Y</au><au>Jin, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum</atitle><jtitle>Journal of biological regulators and homeostatic agents</jtitle><addtitle>J Biol Regul Homeost Agents</addtitle><date>2016-07</date><risdate>2016</risdate><volume>30</volume><issue>3</issue><spage>773</spage><epage>776</epage><pages>773-776</pages><issn>0393-974X</issn><abstract>The objective of this study was to explore the expressions and significance of NDRG1 (N-myc downregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of Condyloma Acuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1, VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significant differences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between the two groups (P less than0.05). The Spearmans Rank-Order Correlation analysis indicated that the expressions of NDRG1 protein and VEGF protein were positively correlated by the Spearmans Rank-Order Correlation analysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA.</abstract><cop>Italy</cop><pmid>27655496</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell Division Condylomata Acuminata - genetics Condylomata Acuminata - metabolism Condylomata Acuminata - pathology Female Gene Expression Regulation Genital Diseases, Female - genetics Genital Diseases, Female - metabolism Genital Diseases, Female - pathology Genital Diseases, Male - genetics Genital Diseases, Male - metabolism Genital Diseases, Male - pathology Humans Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - genetics Ki-67 Antigen - biosynthesis Ki-67 Antigen - genetics Male Middle Aged Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Young Adult |
| title | Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum |
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