Molecular Epidemiological Study of Mumps Epidemics of 2015 in Okinawa, Japan
Although major mumps epidemics occurred every 4–5 years in Okinawa Prefecture in Japan, no laboratory diagnoses were conducted. A mumps epidemic started in Okinawa in October 2014, and we collected clinical samples from 31 patients in 4 areas (Hokubu, Nanbu, Miyako, and Yaeyama) from July to Decembe...
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| Veröffentlicht in: | Japanese Journal of Infectious Diseases 2017, Vol.70(3), pp.329-332 |
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| creator | Kuba, Yumani Kyan, Hisako Arakaki, Eri Takara, Taketoshi Kato, Takashi Okano, Sho Oshiro, Yuko Kudaka, Jun Kidokoro, Minoru |
| description | Although major mumps epidemics occurred every 4–5 years in Okinawa Prefecture in Japan, no laboratory diagnoses were conducted. A mumps epidemic started in Okinawa in October 2014, and we collected clinical samples from 31 patients in 4 areas (Hokubu, Nanbu, Miyako, and Yaeyama) from July to December 2015, for virus isolation and RT-PCR, whose positive ratios were 52% and 87%, respectively. Phylogenetic analyses showed that all isolates were classified into genotype G, and with one exception, consisted of 2 subgenotypes, Ge (55.6%) and Gw (40.7%), which have been prominent in Japan recently. One isolate was classified in another lineage, which was detected in Japan for the first time, and was similar to a Hong Kong isolate from 2014. Remarkably, the geographic distributions of the 2 major lineages were separated. The Ge viruses were isolated from the main island of Okinawa and the Yaeyama Islands, whereas the Gw isolates were mainly detected from the Miyako Islands. These results suggest that the Ge and Gw mumps viruses mainly caused the mumps epidemics of 2015 in Okinawa, and that they spread independently in separate regions. This is the first report describing the molecular epidemiology of mumps epidemics in Okinawa Prefecture. |
| doi_str_mv | 10.7883/yoken.JJID.2016.390 |
| format | Article |
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A mumps epidemic started in Okinawa in October 2014, and we collected clinical samples from 31 patients in 4 areas (Hokubu, Nanbu, Miyako, and Yaeyama) from July to December 2015, for virus isolation and RT-PCR, whose positive ratios were 52% and 87%, respectively. Phylogenetic analyses showed that all isolates were classified into genotype G, and with one exception, consisted of 2 subgenotypes, Ge (55.6%) and Gw (40.7%), which have been prominent in Japan recently. One isolate was classified in another lineage, which was detected in Japan for the first time, and was similar to a Hong Kong isolate from 2014. Remarkably, the geographic distributions of the 2 major lineages were separated. The Ge viruses were isolated from the main island of Okinawa and the Yaeyama Islands, whereas the Gw isolates were mainly detected from the Miyako Islands. These results suggest that the Ge and Gw mumps viruses mainly caused the mumps epidemics of 2015 in Okinawa, and that they spread independently in separate regions. This is the first report describing the molecular epidemiology of mumps epidemics in Okinawa Prefecture.</description><identifier>ISSN: 1344-6304</identifier><identifier>EISSN: 1884-2836</identifier><identifier>DOI: 10.7883/yoken.JJID.2016.390</identifier><identifier>PMID: 28003601</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Child ; Child, Preschool ; Epidemics ; Epidemiology ; Female ; Genotype ; Genotypes ; Geographical distribution ; Humans ; Islands ; Japan - epidemiology ; Male ; Molecular Epidemiology ; Mumps ; Mumps - epidemiology ; mumps virus ; Mumps virus - classification ; Mumps virus - genetics ; Mumps virus - isolation & purification ; Okinawa Prefecture ; Phylogeny ; Polymerase chain reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Viruses</subject><ispartof>Japanese Journal of Infectious Diseases, 2017, Vol.70(3), pp.329-332</ispartof><rights>Authors</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-3bc7d7decd7295afedf34397601f9c950f1591a83f1c3c578fdc5f2ee8c2b55f3</citedby><cites>FETCH-LOGICAL-c618t-3bc7d7decd7295afedf34397601f9c950f1591a83f1c3c578fdc5f2ee8c2b55f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28003601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuba, Yumani</creatorcontrib><creatorcontrib>Kyan, Hisako</creatorcontrib><creatorcontrib>Arakaki, Eri</creatorcontrib><creatorcontrib>Takara, Taketoshi</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Okano, Sho</creatorcontrib><creatorcontrib>Oshiro, Yuko</creatorcontrib><creatorcontrib>Kudaka, Jun</creatorcontrib><creatorcontrib>Kidokoro, Minoru</creatorcontrib><title>Molecular Epidemiological Study of Mumps Epidemics of 2015 in Okinawa, Japan</title><title>Japanese Journal of Infectious Diseases</title><addtitle>Jpn J Infect Dis</addtitle><description>Although major mumps epidemics occurred every 4–5 years in Okinawa Prefecture in Japan, no laboratory diagnoses were conducted. A mumps epidemic started in Okinawa in October 2014, and we collected clinical samples from 31 patients in 4 areas (Hokubu, Nanbu, Miyako, and Yaeyama) from July to December 2015, for virus isolation and RT-PCR, whose positive ratios were 52% and 87%, respectively. Phylogenetic analyses showed that all isolates were classified into genotype G, and with one exception, consisted of 2 subgenotypes, Ge (55.6%) and Gw (40.7%), which have been prominent in Japan recently. One isolate was classified in another lineage, which was detected in Japan for the first time, and was similar to a Hong Kong isolate from 2014. Remarkably, the geographic distributions of the 2 major lineages were separated. The Ge viruses were isolated from the main island of Okinawa and the Yaeyama Islands, whereas the Gw isolates were mainly detected from the Miyako Islands. These results suggest that the Ge and Gw mumps viruses mainly caused the mumps epidemics of 2015 in Okinawa, and that they spread independently in separate regions. This is the first report describing the molecular epidemiology of mumps epidemics in Okinawa Prefecture.</description><subject>Child</subject><subject>Child, Preschool</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Geographical distribution</subject><subject>Humans</subject><subject>Islands</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Molecular Epidemiology</subject><subject>Mumps</subject><subject>Mumps - epidemiology</subject><subject>mumps virus</subject><subject>Mumps virus - classification</subject><subject>Mumps virus - genetics</subject><subject>Mumps virus - isolation & purification</subject><subject>Okinawa Prefecture</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Viruses</subject><issn>1344-6304</issn><issn>1884-2836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1PwyAUhonRuDn9BSamiTde2AmltPTSzKlbtuxCvSaMj9mtLRXamP17qftI9AYIPOc9hweAawSHKaX4YWs2qhpOp5OnYQRRMsQZPAF9RGkcRhQnp_6M4zhMMIx74MK5NYQRIQieg15EIcQJRH0wm5tCibbgNhjXuVRlbgqzygUvgremldvA6GDelrU7PAvXXfmGJMirYLHJK_7N74Mpr3l1Cc40L5y62u8D8PE8fh-9hrPFy2T0OAtFgmgT4qVIZSqVkGmUEa6V1DjGWeoH0pnICNSIZIhTrJHAgqRUS0F0pBQV0ZIQjQfgbpdbW_PVKtewMndCFQWvlGkdQ5SgJKPYaxiA23_o2rS28tMx_4eYZBAmxFN4RwlrnLNKs9rmJbdbhiDrZLNf2ayT3dUlzMv2VTf77HZZKnmsOdj1wGQHrF3DV-oIcNvkolD70BQy3C1_wo-M-OSWqQr_AGMhlNQ</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Kuba, Yumani</creator><creator>Kyan, Hisako</creator><creator>Arakaki, Eri</creator><creator>Takara, Taketoshi</creator><creator>Kato, Takashi</creator><creator>Okano, Sho</creator><creator>Oshiro, Yuko</creator><creator>Kudaka, Jun</creator><creator>Kidokoro, Minoru</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Molecular Epidemiological Study of Mumps Epidemics of 2015 in Okinawa, Japan</title><author>Kuba, Yumani ; 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| subjects | Child Child, Preschool Epidemics Epidemiology Female Genotype Genotypes Geographical distribution Humans Islands Japan - epidemiology Male Molecular Epidemiology Mumps Mumps - epidemiology mumps virus Mumps virus - classification Mumps virus - genetics Mumps virus - isolation & purification Okinawa Prefecture Phylogeny Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction Viruses |
| title | Molecular Epidemiological Study of Mumps Epidemics of 2015 in Okinawa, Japan |
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