Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy

Background: Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a major role in the pathogenesis of isch...

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Veröffentlicht in:	Pediatric research 2017-04, Vol.81 (4), p.654-662
Hauptverfasser:	Shah, Tushar A., Nejad, Jasmine E., Pallera, Haree K., Lattanzio, Frank A., Farhat, Rawad, Kumar, Parvathi S., Hair, Pamela S., Bass, W. Thomas, Krishna, Neel K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/113 692/617/375/3183 692/700/1720/3187 692/700/565 Animals Animals, Newborn Astrocytes - metabolism basic-science-investigation Brain - pathology Brain Diseases - blood Brain Diseases - therapy Complement C3a - analysis Complement C5a - analysis Hypothermia Hypothermia, Induced Hypoxia Hypoxia-Ischemia, Brain - blood Hypoxia-Ischemia, Brain - therapy Ischemia Medicine & Public Health Microglia - metabolism Neurons - metabolism Pathogenesis Pediatric Surgery Pediatrics Rats Rats, Wistar Reperfusion Injury Temperature Time Factors
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