Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix

ABSTRACT Metastatic involvement in vertebral bone diminishes the mechanical integrity of the spine; however minimal data exist on the potential impact of metastases on the intrinsic material characteristics of the bone matrix. Thirty‐four (34) female athymic rats were inoculated with HeLa (N = 17) o...

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Veröffentlicht in:	Journal of orthopaedic research 2016-12, Vol.34 (12), p.2126-2136
Hauptverfasser:	Burke, Mikhail V., Atkins, Ayelet, Akens, Margarete, Willett, Thomas L., Whyne, Cari M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone/bone biology cancer Carcinoma - metabolism Carcinoma - secondary Collagen - metabolism Female HeLa Cells Humans Hydroxylation Osteolysis Oxidative Stress Proline - metabolism Random Allocation Rats, Nude Spinal Neoplasms - metabolism Spinal Neoplasms - secondary spine Thoracic Vertebrae - metabolism tumors
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