In vitro and in vivo activities of the diazabicyclooctane OP0595 against AmpC-derepressed Pseudomonas aeruginosa

Pseudomonas aeruginosa is a common cause for healthcare-associated infections, which have been historically treated by antipseudomonal β-lactam agents in the clinical setting. However, P. aeruginosa has evolved to overcome these β-lactam agents via multiple endogenous resistance mechanisms, includin...

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Veröffentlicht in:	Journal of antibiotics 2017-03, Vol.70 (3), p.246-250
Hauptverfasser:	Morinaka, Akihiro, Tsutsumi, Yuko, Yamada, Keiko, Takayama, Yoshihiro, Sakakibara, Shiro, Takata, Toshihiko, Abe, Takao, Furuuchi, Takeshi, Inamura, Seiichi, Sakamaki, Yoshiaki, Tsujii, Nakako, Ida, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/1318 631/326/22/1290 631/92/436 692/700/565/1436/1437 Amides Animals Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics Azabicyclo Compounds - pharmacology Bacterial Proteins - genetics Bacteriology beta-Lactam Resistance beta-Lactamase Inhibitors - pharmacology beta-Lactamases - genetics beta-Lactams - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Cefepime Cephalosporinase Derepression Humans In vivo methods and tests Infections Lactams - pharmacology Life Sciences Male Medicinal Chemistry Meropenem Mice Mice, Inbred ICR Microbial Sensitivity Tests Microbiology Neutropenia Neutropenia - complications Organic Chemistry original-article Piperacillin Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Thigh β Lactamase β-Lactam antibiotics
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