Clinical translation of polymyxin-based combination therapy: Facts, challenges and future opportunities

Summary The emergence and spread of multidrug resistant Gram-negative bacteria has led to a resurgence in the clinical use of polymyxin antibiotics. However, the prevalence of polymyxin resistance is on the rise at an alarming rate, motivating the idea of combination therapy to sustain the revival o...

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Veröffentlicht in:	The Journal of infection 2017-02, Vol.74 (2), p.118-130
Hauptverfasser:	Zhang, Xueli, Guo, Fengmei, Shao, Hua, Zheng, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Clinical translation Colistin - administration & dosage Colistin - adverse effects Colistin - pharmacology Colistin - therapeutic use Combination therapy Drug Resistance, Multiple, Bacterial Drug Therapy, Combination Gram-Negative Bacteria - drug effects Gram-Negative Bacterial Infections - drug therapy Humans Infectious Disease Klebsiella pneumoniae - drug effects Microbial Sensitivity Tests Multidrug resistance Polymyxin B - administration & dosage Polymyxin B - adverse effects Polymyxin B - pharmacology Polymyxin B - therapeutic use Polymyxins Polymyxins - adverse effects Polymyxins - pharmacology Polymyxins - therapeutic use Pseudomonas aeruginosa - drug effects Translational Medical Research
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