Efficient Tumor Accumulation, Penetration and Tumor Growth Inhibition Achieved by Polymer Therapeutics: The Effect of Polymer Architectures

To obtain high tumor-specific accumulation, strong tumor penetration and low off-target uptake, we developed a series of polymer therapeutics with different architectures, including random, block, and brush-like structure, based on the classic N-(2-hydroxypropyl) methacrylamide polymers. The influen...

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Veröffentlicht in:	Biomacromolecules 2017-01, Vol.18 (1), p.217-230
Hauptverfasser:	Shen, Tong, Xu, Xin, Guo, Linyi, Tang, Hao, Diao, Tongxiang, Gan, Zhihua, Zhang, Guan, Yu, Qingsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Cell Survival - drug effects Doxorubicin - pharmacology Female Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Methacrylates - chemistry Mice Mice, Inbred BALB C Micelles Polymers - administration & dosage Polymers - chemistry Tumor Cells, Cultured
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