Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase
Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma. TG and RLP-TG together...
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| Veröffentlicht in: | Clinica chimica acta 2017-02, Vol.465, p.45-52 |
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| creator | Nakajima, Katsuyuki Tokita, Yoshiharu Sakamaki, Koji Shimomura, Younosuke Kobayashi, Junji Kamachi, Keiko Tanaka, Akira Stanhope, Kimber L. Havel, Peter J. Wang, Tao Machida, Tetsuo Murakami, Masami |
| description | Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma.
TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal.
Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
•Non-fasting plasma TG was suggested to be higher risk factor than fasting TG.•RLP-TG/TG was significantly higher in postprandial plasma than in fasting plasma.•The RLP-TG/RL-C ratio was higher in postprandial plasma than in fasting plasma.•Large RLP is associated with a lower amount of LPL compared with small RLP. |
| doi_str_mv | 10.1016/j.cca.2016.12.011 |
| format | Article |
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TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal.
Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
•Non-fasting plasma TG was suggested to be higher risk factor than fasting TG.•RLP-TG/TG was significantly higher in postprandial plasma than in fasting plasma.•The RLP-TG/RL-C ratio was higher in postprandial plasma than in fasting plasma.•Large RLP is associated with a lower amount of LPL compared with small RLP.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2016.12.011</identifier><identifier>PMID: 27986550</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Cardiovascular Diseases - blood ; Case-Control Studies ; Eating - physiology ; Fasting - blood ; Fasting and postprandial plasma ; Female ; Food intake (fat load) ; Hepatic triglyceride lipase (HTGL) ; Humans ; Lipoprotein lipase (LPL) ; Lipoprotein Lipase - blood ; Lipoproteins - blood ; Male ; Middle Aged ; Particle Size ; Remnant lipoproteins (RLP) ; Risk Factors ; RLP-C ; RLP-TG ; Triglycerides (TG) ; Triglycerides - blood</subject><ispartof>Clinica chimica acta, 2017-02, Vol.465, p.45-52</ispartof><rights>2016 The Authors</rights><rights>Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-9d897b3963e66191d0b1b93c42ca1895388c4ac49ffe4329861c3a619fd6cf563</citedby><cites>FETCH-LOGICAL-c396t-9d897b3963e66191d0b1b93c42ca1895388c4ac49ffe4329861c3a619fd6cf563</cites><orcidid>0000-0002-1760-4922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2016.12.011$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27986550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Katsuyuki</creatorcontrib><creatorcontrib>Tokita, Yoshiharu</creatorcontrib><creatorcontrib>Sakamaki, Koji</creatorcontrib><creatorcontrib>Shimomura, Younosuke</creatorcontrib><creatorcontrib>Kobayashi, Junji</creatorcontrib><creatorcontrib>Kamachi, Keiko</creatorcontrib><creatorcontrib>Tanaka, Akira</creatorcontrib><creatorcontrib>Stanhope, Kimber L.</creatorcontrib><creatorcontrib>Havel, Peter J.</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Machida, Tetsuo</creatorcontrib><creatorcontrib>Murakami, Masami</creatorcontrib><title>Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma.
TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal.
Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
•Non-fasting plasma TG was suggested to be higher risk factor than fasting TG.•RLP-TG/TG was significantly higher in postprandial plasma than in fasting plasma.•The RLP-TG/RL-C ratio was higher in postprandial plasma than in fasting plasma.•Large RLP is associated with a lower amount of LPL compared with small RLP.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiovascular Diseases - blood</subject><subject>Case-Control Studies</subject><subject>Eating - physiology</subject><subject>Fasting - blood</subject><subject>Fasting and postprandial plasma</subject><subject>Female</subject><subject>Food intake (fat load)</subject><subject>Hepatic triglyceride lipase (HTGL)</subject><subject>Humans</subject><subject>Lipoprotein lipase (LPL)</subject><subject>Lipoprotein Lipase - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Particle Size</subject><subject>Remnant lipoproteins (RLP)</subject><subject>Risk Factors</subject><subject>RLP-C</subject><subject>RLP-TG</subject><subject>Triglycerides (TG)</subject><subject>Triglycerides - blood</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFvFCEUhYnR2G3rD_DF8OjLjNxhZhbik2lq26SJL-0zYS-XyjrDrMBq9i_4q2Wz1fjkEwf4ziGXw9hbEC0IGD9sW0TbdlW20LUC4AVbgVrLRva6e8lWQgjdKK3gjJ3nvK3bXozwmp11a63GYRAr9ushhafpgJSCI45LLBQLD5EnmqOtcgq7ZZeWQiFmHjLP4SkGH7DeTYcKYiKbyXHrCyXul8XVw2K_EbfRHQ025wWDLZX5GcpXvptsnu2_uUddMy7ZK2-nTG-e1wv2-Pn64eq2uf9yc3f16b5BqcfSaKf0elOlpHEEDU5sYKMl9h1aUHqQSmFvsdfeUy-7OiigtJX0bkQ_jPKCvT_l1ue_7ykXM4eMNE020rLPBtQAUkCnRUXhhGJack7kzS6F2aaDAWGOFZitqRWYYwUGOlMrqJ53z_H7zUzur-PPn1fg4wmgOuSPQMlkDBSRXEiExbgl_Cf-N4W9mbY</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Nakajima, Katsuyuki</creator><creator>Tokita, Yoshiharu</creator><creator>Sakamaki, Koji</creator><creator>Shimomura, Younosuke</creator><creator>Kobayashi, Junji</creator><creator>Kamachi, Keiko</creator><creator>Tanaka, Akira</creator><creator>Stanhope, Kimber L.</creator><creator>Havel, Peter J.</creator><creator>Wang, Tao</creator><creator>Machida, Tetsuo</creator><creator>Murakami, Masami</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1760-4922</orcidid></search><sort><creationdate>201702</creationdate><title>Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase</title><author>Nakajima, Katsuyuki ; Tokita, Yoshiharu ; Sakamaki, Koji ; Shimomura, Younosuke ; Kobayashi, Junji ; Kamachi, Keiko ; Tanaka, Akira ; Stanhope, Kimber L. ; Havel, Peter J. ; Wang, Tao ; Machida, Tetsuo ; Murakami, Masami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-9d897b3963e66191d0b1b93c42ca1895388c4ac49ffe4329861c3a619fd6cf563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiovascular Diseases - blood</topic><topic>Case-Control Studies</topic><topic>Eating - physiology</topic><topic>Fasting - blood</topic><topic>Fasting and postprandial plasma</topic><topic>Female</topic><topic>Food intake (fat load)</topic><topic>Hepatic triglyceride lipase (HTGL)</topic><topic>Humans</topic><topic>Lipoprotein lipase (LPL)</topic><topic>Lipoprotein Lipase - blood</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Particle Size</topic><topic>Remnant lipoproteins (RLP)</topic><topic>Risk Factors</topic><topic>RLP-C</topic><topic>RLP-TG</topic><topic>Triglycerides (TG)</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakajima, Katsuyuki</creatorcontrib><creatorcontrib>Tokita, Yoshiharu</creatorcontrib><creatorcontrib>Sakamaki, Koji</creatorcontrib><creatorcontrib>Shimomura, Younosuke</creatorcontrib><creatorcontrib>Kobayashi, Junji</creatorcontrib><creatorcontrib>Kamachi, Keiko</creatorcontrib><creatorcontrib>Tanaka, Akira</creatorcontrib><creatorcontrib>Stanhope, Kimber L.</creatorcontrib><creatorcontrib>Havel, Peter J.</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Machida, Tetsuo</creatorcontrib><creatorcontrib>Murakami, Masami</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakajima, Katsuyuki</au><au>Tokita, Yoshiharu</au><au>Sakamaki, Koji</au><au>Shimomura, Younosuke</au><au>Kobayashi, Junji</au><au>Kamachi, Keiko</au><au>Tanaka, Akira</au><au>Stanhope, Kimber L.</au><au>Havel, Peter J.</au><au>Wang, Tao</au><au>Machida, Tetsuo</au><au>Murakami, Masami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2017-02</date><risdate>2017</risdate><volume>465</volume><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma.
TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal.
Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
•Non-fasting plasma TG was suggested to be higher risk factor than fasting TG.•RLP-TG/TG was significantly higher in postprandial plasma than in fasting plasma.•The RLP-TG/RL-C ratio was higher in postprandial plasma than in fasting plasma.•Large RLP is associated with a lower amount of LPL compared with small RLP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27986550</pmid><doi>10.1016/j.cca.2016.12.011</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1760-4922</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Cardiovascular Diseases - blood Case-Control Studies Eating - physiology Fasting - blood Fasting and postprandial plasma Female Food intake (fat load) Hepatic triglyceride lipase (HTGL) Humans Lipoprotein lipase (LPL) Lipoprotein Lipase - blood Lipoproteins - blood Male Middle Aged Particle Size Remnant lipoproteins (RLP) Risk Factors RLP-C RLP-TG Triglycerides (TG) Triglycerides - blood |
| title | Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase |
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