Asymmetric One-Pot Synthesis of (3R,3aS,6aR)‑Hexahydrofuro[2,3‑b]furan-3-ol: A Key Component of Current HIV Protease Inhibitors

A concise and efficient synthesis of (3R,3aS,6aR)-hexahydrofuro­[2,3-b]­furan-3-ol, a key building block for several clinical and experimental HIV protease inhibitors including the highly important drug darunavir, was achieved via a one-pot procedure using furan and Cbz-protected glycol aldehyde as...

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Veröffentlicht in:	Journal of organic chemistry 2017-01, Vol.82 (2), p.1218-1223
Hauptverfasser:	Sevenich, Adrian, Liu, Gong-Qing, Arduengo, Anthony J, Gupton, B. Frank, Opatz, Till
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Organic - methods Furans - chemical synthesis Furans - chemistry HIV Protease Inhibitors - chemical synthesis Molecular Structure Stereoisomerism
Online-Zugang:	Volltext
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