Role of endoplasmic reticulum stress in disuse osteoporosis

Abstract Osteoporosis is a major skeletal disease with low bone mineral density, which leads to an increased risk of bone fracture. Salubrinal is a synthetic chemical that inhibits dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) in response to endoplasmic reticulum (ER)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2017-04, Vol.97, p.2-14
Hauptverfasser:	Li, Jie, Yang, Shuang, Li, Xinle, Liu, Daquan, Wang, Zhaonan, Guo, Jialu, Tan, Nian, Gao, Zhe, Zhao, Xiaoyu, Zhang, Jiuguo, Gou, Fanglin, Yokota, Hiroki, Zhang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Body Weight Bone Resorption - drug therapy Bone Resorption - pathology Cell Count Cell Differentiation - drug effects Cell Survival - drug effects Cinnamates - pharmacology Cinnamates - therapeutic use Colony-Forming Units Assay Disuse Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Eukaryotic translation initiation factor 2α Female Femur - diagnostic imaging Femur - drug effects Femur - pathology Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Hindlimb Suspension Hindlimb unloading Mice, Inbred C57BL Muscular Disorders, Atrophic - complications Muscular Disorders, Atrophic - drug therapy Muscular Disorders, Atrophic - pathology NFATC Transcription Factors - metabolism Orthopedics Osteoblasts - pathology Osteoblasts - ultrastructure Osteoclasts - pathology Osteogenesis - drug effects Osteoporosis Osteoporosis - complications Osteoporosis - diagnostic imaging Osteoporosis - drug therapy Osteoporosis - pathology Salubrinal Thiourea - analogs & derivatives Thiourea - pharmacology Thiourea - therapeutic use X-Ray Microtomography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!