Specific targeting delivery to MUC1 overexpressing tumors by albumin-chitosan nanoparticles conjugated to DNA aptamer

[Display omitted] Chitosan-coated human serum albumin nanoparticles were functionalized by MUC1 aptamer to obtain a selective drug carrier toward cancers overexpressing MUC1. The negative charges of albumin nanoparticles were shifted to positive charges by surface modification with chitosan, and MUC...

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Veröffentlicht in:	International journal of pharmaceutics 2016-12, Vol.515 (1-2), p.607-615
Hauptverfasser:	Esfandyari-Manesh, Mehdi, Mohammadi, Ali, Atyabi, Fatemeh, Nabavi, Seyedeh Maryam, Ebrahimi, Seyedeh Masoumeh, Shahmoradi, Elnaz, Varnamkhasti, Behrang Shiri, Ghahremani, Mohammad Hossein, Dinarvand, Rassoul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Line, Tumor Chitosan - administration & dosage Chitosan - chemistry Chitosan - pharmacokinetics Chitosan-coated albumin Drug Carriers - administration & dosage Drug Carriers - pharmacokinetics Female Humans MCF-7 Cells Molecular Targeted Therapy MUC1 aptamer Mucin-1 - biosynthesis Mucin-1 - genetics Mucin-1 - metabolism Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Paclitaxel - pharmacology Serum Albumin - administration & dosage Serum Albumin - chemistry Serum Albumin - pharmacokinetics Specific targeting Surface modification
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