Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study

Diffuse-type tenosynovial giant cell tumor (D-T TSGCT) is regarded as a benign but locally aggressive neoplasm with significant recurrent potential. We report a case of malignant (D-T TSGCT with pleural metastases arising in the left knee in a 57-year-old male. The tumor demonstrated atypical featur...

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Veröffentlicht in:	Human pathology 2017-05, Vol.63, p.144-148
Hauptverfasser:	Alexiev, Borislav A, Tumer, Yanki, Yang, Guang-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amputation Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biopsy Cancer therapies CDKN2A/B loss Cyclin-Dependent Kinase Inhibitor p15 - analysis Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p18 - analysis Cyclin-Dependent Kinase Inhibitor p18 - genetics Gangrene Genomes Giant cell tumor Giant Cell Tumor of Tendon Sheath - chemistry Giant Cell Tumor of Tendon Sheath - diagnosis Giant Cell Tumor of Tendon Sheath - genetics Giant Cell Tumor of Tendon Sheath - secondary Giant Cell Tumor of Tendon Sheath - surgery High-Throughput Nucleotide Sequencing Histology Humans Immunohistochemistry Knee Joint - chemistry Knee Joint - diagnostic imaging Knee Joint - pathology Knee Joint - surgery Magnetic Resonance Imaging Male Medical imaging Metastases Metastasis Middle Aged Molecular Diagnostic Techniques NMR Nuclear magnetic resonance Pathology Pleural Neoplasms - chemistry Pleural Neoplasms - diagnosis Pleural Neoplasms - genetics Pleural Neoplasms - secondary Positron Emission Tomography Computed Tomography Predictive Value of Tests Proto-Oncogene Proteins c-mdm2 - analysis Sequence Analysis, DNA Sequence Analysis, RNA Studies Time Factors Tomography Treatment Outcome Tumors
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