Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle

Eukaryotic cell division is known to be controlled by the cyclin/cyclin dependent kinase (CDK) machinery. However, eukaryotes have evolved prior to CDKs, and cells can divide in the absence of major cyclin/CDK components. We hypothesized that an autonomous metabolic oscillator provides dynamic trigg...

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Veröffentlicht in:	Molecular cell 2017-01, Vol.65 (2), p.285-295
Hauptverfasser:	Papagiannakis, Alexandros, Niebel, Bastian, Wit, Ernst C., Heinemann, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Cell Cycle coupled oscillators Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism cyclin/CDK machinery Energy Metabolism FRET sensor Genotype metabolic oscillations microfluidics Microscopy, Fluorescence Microscopy, Video Models, Biological Mutation NAD(P)H NADP - metabolism Oscillometry Periodicity Phenotype Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism single cell Time Factors yeast metabolic cycle
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