Quantitative systems pharmacology: a promising approach for translational pharmacology

Biopharmaceutical companies have increasingly been exploring Quantitative Systems Pharmacology (QSP) as a potential avenue to address current challenges in drug development. In this paper, we discuss the application of QSP modeling approaches to address challenges in the translational of preclinical...

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Veröffentlicht in:	Drug discovery today. Technologies 2016-09, Vol.21-22, p.57-65
Hauptverfasser:	Gadkar, K., Kirouac, D., Parrott, N., Ramanujan, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Asthma - drug therapy Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Humans Models, Biological Mutation Neoplasms - drug therapy Neoplasms - genetics Oseltamivir - pharmacokinetics Oseltamivir - pharmacology Pharmacology, Clinical - methods Proto-Oncogene Proteins B-raf - genetics Systems Biology Translational Medical Research
Online-Zugang:	Volltext
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