Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study

Highlights • Among 2440 AML patients, the incidence of invasive aspergillosis (IA) was 6.4%. • Among 627 ALL patients, the incidence of IA was 3.8%. • Mortality of IA at Day 84 was 33.8% ( n = 49) and attributable mortality was 26.9% ( n = 39). • Only two episodes of IA due to azole-resistant Aspe...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-02, Vol.49 (2), p.218-223
Hauptverfasser:	Koehler, Philipp, Hamprecht, Axel, Bader, Oliver, Bekeredjian-Ding, Isabelle, Buchheidt, Dieter, Doelken, Gottfried, Elias, Johannes, Haase, Gerhard, Hahn-Ast, Corinna, Karthaus, Meinolf, Kekulé, Alexander, Keller, Peter, Kiehl, Michael, Krause, Stefan W, Krämer, Carolin, Neumann, Silke, Rohde, Holger, La Rosée, Paul, Ruhnke, Markus, Schafhausen, Philippe, Schalk, Enrico, Schulz, Katrin, Schwartz, Stefan, Silling, Gerda, Staib, Peter, Ullmann, Andrew, Vergoulidou, Maria, Weber, Thomas, Cornely, Oliver A, Vehreschild, Maria J.G.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukaemia Acute myeloid leukaemia Adolescent Adult Aged Aged, 80 and over Animals Antifungal Agents - pharmacology Aspergillus - drug effects Aspergillus - isolation & purification Aspergillus fumigatus Azoles - pharmacology Drug Resistance, Fungal Female Germany - epidemiology Humans Incidence Infectious Disease Invasive Pulmonary Aspergillosis - epidemiology Invasive Pulmonary Aspergillosis - microbiology Leukemia, Myeloid, Acute - complications Male Middle Aged Posaconazole Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Prospective Studies Voriconazole Young Adult
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Zusammenfassung:	Highlights • Among 2440 AML patients, the incidence of invasive aspergillosis (IA) was 6.4%. • Among 627 ALL patients, the incidence of IA was 3.8%. • Mortality of IA at Day 84 was 33.8% ( n = 49) and attributable mortality was 26.9% ( n = 39). • Only two episodes of IA due to azole-resistant Aspergillus fumigatus were observed. • A change of antifungal treatment practices in Germany does not appear warranted.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.10.019