Wound scabs protect regenerating tissue against harmful ultraviolet radiation
Abstract Benefits attributed to wound scabs include prevention of blood loss and protection against infection. However, when formation of a wound scab is prevented, the risk of infection is reduced. Moreover, in the absence of a wound scab, wounds heal faster and scar formation is reduced. The quest...
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| Veröffentlicht in: | Medical hypotheses 2016-11, Vol.96, p.39-41 |
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| container_title | Medical hypotheses |
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| creator | van der Pol, E Mudde, Y.D Coumans, F.A.W van Leeuwen, T.G Sturk, A Nieuwland, R |
| description | Abstract Benefits attributed to wound scabs include prevention of blood loss and protection against infection. However, when formation of a wound scab is prevented, the risk of infection is reduced. Moreover, in the absence of a wound scab, wounds heal faster and scar formation is reduced. The question arises why we develop a wound scab. Here we show that wound scabs inhibit transmission of ultraviolet radiation (UVR). We compared the UVR transmittance of human wound scabs to sunscreen by measuring the sun protection factor (SPF) with diffuse transmittance spectroscopy. Three wound scabs showed SPFs of 70, 84, and 300, which is more effective than the most protective commercially available sun block. Because our results demonstrate that a wound scab offers natural protection against UVR, and because no beneficial trait is attributed to wound scabs, we hypothesize that the main function of wound scabs is to limit DNA damage in underlying cells during regeneration of wound tissue exposed to sunlight, thereby reducing the risk of developing skin cancer. |
| doi_str_mv | 10.1016/j.mehy.2016.09.011 |
| format | Article |
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However, when formation of a wound scab is prevented, the risk of infection is reduced. Moreover, in the absence of a wound scab, wounds heal faster and scar formation is reduced. The question arises why we develop a wound scab. Here we show that wound scabs inhibit transmission of ultraviolet radiation (UVR). We compared the UVR transmittance of human wound scabs to sunscreen by measuring the sun protection factor (SPF) with diffuse transmittance spectroscopy. Three wound scabs showed SPFs of 70, 84, and 300, which is more effective than the most protective commercially available sun block. Because our results demonstrate that a wound scab offers natural protection against UVR, and because no beneficial trait is attributed to wound scabs, we hypothesize that the main function of wound scabs is to limit DNA damage in underlying cells during regeneration of wound tissue exposed to sunlight, thereby reducing the risk of developing skin cancer.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1016/j.mehy.2016.09.011</identifier><identifier>PMID: 27959273</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Cicatrix ; DNA Damage ; Humans ; Internal Medicine ; Regeneration ; Risk ; Skin - pathology ; Skin - radiation effects ; Skin Neoplasms - prevention & control ; Solar System ; Spectrophotometry ; Spectrophotometry, Ultraviolet ; Ultraviolet Rays ; Wound Healing</subject><ispartof>Medical hypotheses, 2016-11, Vol.96, p.39-41</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. 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However, when formation of a wound scab is prevented, the risk of infection is reduced. Moreover, in the absence of a wound scab, wounds heal faster and scar formation is reduced. The question arises why we develop a wound scab. Here we show that wound scabs inhibit transmission of ultraviolet radiation (UVR). We compared the UVR transmittance of human wound scabs to sunscreen by measuring the sun protection factor (SPF) with diffuse transmittance spectroscopy. Three wound scabs showed SPFs of 70, 84, and 300, which is more effective than the most protective commercially available sun block. Because our results demonstrate that a wound scab offers natural protection against UVR, and because no beneficial trait is attributed to wound scabs, we hypothesize that the main function of wound scabs is to limit DNA damage in underlying cells during regeneration of wound tissue exposed to sunlight, thereby reducing the risk of developing skin cancer.</description><subject>Cicatrix</subject><subject>DNA Damage</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Regeneration</subject><subject>Risk</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Solar System</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Ultraviolet Rays</subject><subject>Wound Healing</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVoabZpv0AOxcde7GqktWRDKITQf5DQQxJ6FLPSeKOtLSeSHdhvH5lNeughJ43gvcfM7zF2CrwCDurLrhrobl-JPFe8rTjAEVtBLUUptNZv2IpLrsq20fqYvU9pxzlv17J5x46FbutWaLliV3_GObgiWdyk4j6OE9mpiLSlQBEnH7bF5FOaqcAt-pCm4g7j0M19MfdTxEc_9pT16HwWj-EDe9thn-jj83vCbr9_u7n4WV7-_vHr4vyytGutp1K5DiVI1A3oPGnQQhBypVC4TauE2tgaG-StlY2zAMIJXiup8w-b9bqTJ-zzITdv_DBTmszgk6W-x0DjnAw0NYhG5RuzVBykNo4pRerMffQDxr0BbhaMZmcWjGbBaHhrMsZs-vScP28Gcv8sL9yy4OwgoHzlo6dokvUULDkfM0HjRv96_tf_7Lb3wVvs_9Ke0m6cY8j8DJgkDDfXS5FLj6Akh9yhfAKPxJlC</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>van der Pol, E</creator><creator>Mudde, Y.D</creator><creator>Coumans, F.A.W</creator><creator>van Leeuwen, T.G</creator><creator>Sturk, A</creator><creator>Nieuwland, R</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Wound scabs protect regenerating tissue against harmful ultraviolet radiation</title><author>van der Pol, E ; Mudde, Y.D ; Coumans, F.A.W ; van Leeuwen, T.G ; Sturk, A ; Nieuwland, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-6dfa313a7817fa371722ea066a2db9626bc5a8a09c38dc112d20563738da844f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cicatrix</topic><topic>DNA Damage</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Regeneration</topic><topic>Risk</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Solar System</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Ultraviolet Rays</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Pol, E</creatorcontrib><creatorcontrib>Mudde, Y.D</creatorcontrib><creatorcontrib>Coumans, F.A.W</creatorcontrib><creatorcontrib>van Leeuwen, T.G</creatorcontrib><creatorcontrib>Sturk, A</creatorcontrib><creatorcontrib>Nieuwland, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Pol, E</au><au>Mudde, Y.D</au><au>Coumans, F.A.W</au><au>van Leeuwen, T.G</au><au>Sturk, A</au><au>Nieuwland, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wound scabs protect regenerating tissue against harmful ultraviolet radiation</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>96</volume><spage>39</spage><epage>41</epage><pages>39-41</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>Abstract Benefits attributed to wound scabs include prevention of blood loss and protection against infection. However, when formation of a wound scab is prevented, the risk of infection is reduced. Moreover, in the absence of a wound scab, wounds heal faster and scar formation is reduced. The question arises why we develop a wound scab. Here we show that wound scabs inhibit transmission of ultraviolet radiation (UVR). We compared the UVR transmittance of human wound scabs to sunscreen by measuring the sun protection factor (SPF) with diffuse transmittance spectroscopy. Three wound scabs showed SPFs of 70, 84, and 300, which is more effective than the most protective commercially available sun block. Because our results demonstrate that a wound scab offers natural protection against UVR, and because no beneficial trait is attributed to wound scabs, we hypothesize that the main function of wound scabs is to limit DNA damage in underlying cells during regeneration of wound tissue exposed to sunlight, thereby reducing the risk of developing skin cancer.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27959273</pmid><doi>10.1016/j.mehy.2016.09.011</doi><tpages>3</tpages></addata></record> |
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| ispartof | Medical hypotheses, 2016-11, Vol.96, p.39-41 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cicatrix DNA Damage Humans Internal Medicine Regeneration Risk Skin - pathology Skin - radiation effects Skin Neoplasms - prevention & control Solar System Spectrophotometry Spectrophotometry, Ultraviolet Ultraviolet Rays Wound Healing |
| title | Wound scabs protect regenerating tissue against harmful ultraviolet radiation |
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