BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes

Abstract Background Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and its target genes are intimately associated with the metastasis possibi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-12, Vol.84, p.191-198
Hauptverfasser:	Davudian, Sadaf, Shajari, Neda, Kazemi, Tohid, Mansoori, Behzad, Salehi, Shima, Mohammadi, Ali, Shanehbandi, Dariush, Shahgoli, Vahid Khaze, Asadi, Milad, Baradaran, Behzad
Format:	Artikel
Sprache:	eng
Schlagworte:	BACH1 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Blotting, Western Cancer Cell Movement Cell Survival Colon Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Fanconi Anemia Complementation Group Proteins - genetics Fanconi Anemia Complementation Group Proteins - metabolism Gene Expression Regulation, Neoplastic HMGA2 Protein - genetics HMGA2 Protein - metabolism HT29 Cells Humans Internal Medicine Knockdown Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Medical Education Migration Neoplasm Metastasis Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction siRNA Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Time Factors Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!