Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells

Panax ginseng is one of the most well-known medicinal herbs in Korea and China, which has been used for treatment and prevention of cancer, obesity, diabetes, and cardiovascular diseases. Ginsenosides are the major components of P. ginseng, having a wide range of pharmacological activities. Among th...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-12, Vol.194, p.83-90
Hauptverfasser:	Han, Songhee, Jeong, Ae Jin, Yang, Heejung, Bin Kang, Kyo, Lee, Haeri, Yi, Eun Hee, Kim, Byung-Hak, Cho, Chung-Hyun, Chung, Jin Woong, Sung, Sang Hyun, Ye, Sang-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Cell Line, Tumor Colorectal cancer (CRC) Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - metabolism Doxorubicin - pharmacology Drug Synergism Ginsenoside 20(S)-Rh2 Ginsenosides - pharmacology Ginsenosides - therapeutic use Humans Interleukin-6 (IL-6) Interleukin-6 - antagonists & inhibitors Interleukin-6 - physiology Janus Kinase 2 - metabolism Matrix metalloproteinase (MMP) Matrix Metalloproteinases - metabolism Signal transducer and activator of transcription 3 (STAT3) Signal Transduction - drug effects STAT3 Transcription Factor - metabolism
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