Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage
We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2016/08/15, Vol.55(16), pp.2241-2246 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2246 |
|---|---|
| container_issue | 16 |
| container_start_page | 2241 |
| container_title | Internal Medicine |
| container_volume | 55 |
| creator | Chino, Haruka Sekine, Akimasa Baba, Tomohisa Iwasawa, Tae Okudela, Koji Takemura, Tamiko Itoh, Harumi Sato, Shinji Suzuki, Yasuo Ogura, Takashi |
| description | We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD. |
| doi_str_mv | 10.2169/internalmedicine.55.5774 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1851250649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811842082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c617t-2edc7ecccb92eeade867dc548947005a44dc574228becfcbc6c900ea90d7cc2a3</originalsourceid><addsrcrecordid>eNqNkcGO0zAQhiMEYsvCKyAfuaRrO3GccKvahV2pqNUKztHEmXS9cu1iOyv1kXhLnHbpAXHgYntmvn9m5D_LCKNzzqrmRtuI3oLZY6-VtjgXYi6kLF9lM1aUTS55IV5nM9qwOufpuMrehfBEaVHLhr_NrrgUvKCUz7JfD9BrZ9xOKzAEbE-2EB8viaXzHg1E7SzRlixs1Pm31UKcXp3rj_nBBR31M5L7aacQU5B069HuyEoHhICfyQMcdG-OZOvdzmMIE75Fr43rRgOebA6gkg7DaYGVHoYxIFmYZ3RTeQV72OH77M0AJuCHl_s6-_Hl9vvyLl9vvt4vF-tcVUzGnGOvJCqluoYjQo91JXslyropJaUCyjJFsuS87lANqlOVaihFaGgvleJQXGefzn0P3v0cMcR2r4NCY8CiG0PLasG4oFXZ_AfKWF1yWvOE1mdUeReCx6E9eL0Hf2wZbSdP2789bYVoJ0-T9OPLlLFLxYvwj4kJ2JyBpxDTR10A8FErg__szKpT__OIC6kewbdoi9-EbMRq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1811842082</pqid></control><display><type>article</type><title>Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage</title><source>J-STAGE Free</source><source>MEDLINE</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Chino, Haruka ; Sekine, Akimasa ; Baba, Tomohisa ; Iwasawa, Tae ; Okudela, Koji ; Takemura, Tamiko ; Itoh, Harumi ; Sato, Shinji ; Suzuki, Yasuo ; Ogura, Takashi</creator><creatorcontrib>Chino, Haruka ; Sekine, Akimasa ; Baba, Tomohisa ; Iwasawa, Tae ; Okudela, Koji ; Takemura, Tamiko ; Itoh, Harumi ; Sato, Shinji ; Suzuki, Yasuo ; Ogura, Takashi</creatorcontrib><description>We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.55.5774</identifier><identifier>PMID: 27523002</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>anti-melanoma differentiation-associated protein 5 antibody ; Autoantibodies - blood ; Biomarkers - blood ; clinically amyopathic dermatomyositis ; Cyclic N-Oxides - blood ; Humans ; Lung Diseases, Interstitial - blood ; Lung Diseases, Interstitial - diagnostic imaging ; Male ; Middle Aged ; perilobular opacities ; Pulmonary Alveoli ; radiological and pathological correlation ; rapidly-progressive interstitial lung disease ; surgical lung biopsy ; Tomography, X-Ray Computed</subject><ispartof>Internal Medicine, 2016/08/15, Vol.55(16), pp.2241-2246</ispartof><rights>2016 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-2edc7ecccb92eeade867dc548947005a44dc574228becfcbc6c900ea90d7cc2a3</citedby><cites>FETCH-LOGICAL-c617t-2edc7ecccb92eeade867dc548947005a44dc574228becfcbc6c900ea90d7cc2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27523002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chino, Haruka</creatorcontrib><creatorcontrib>Sekine, Akimasa</creatorcontrib><creatorcontrib>Baba, Tomohisa</creatorcontrib><creatorcontrib>Iwasawa, Tae</creatorcontrib><creatorcontrib>Okudela, Koji</creatorcontrib><creatorcontrib>Takemura, Tamiko</creatorcontrib><creatorcontrib>Itoh, Harumi</creatorcontrib><creatorcontrib>Sato, Shinji</creatorcontrib><creatorcontrib>Suzuki, Yasuo</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><title>Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD.</description><subject>anti-melanoma differentiation-associated protein 5 antibody</subject><subject>Autoantibodies - blood</subject><subject>Biomarkers - blood</subject><subject>clinically amyopathic dermatomyositis</subject><subject>Cyclic N-Oxides - blood</subject><subject>Humans</subject><subject>Lung Diseases, Interstitial - blood</subject><subject>Lung Diseases, Interstitial - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>perilobular opacities</subject><subject>Pulmonary Alveoli</subject><subject>radiological and pathological correlation</subject><subject>rapidly-progressive interstitial lung disease</subject><subject>surgical lung biopsy</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAQhiMEYsvCKyAfuaRrO3GccKvahV2pqNUKztHEmXS9cu1iOyv1kXhLnHbpAXHgYntmvn9m5D_LCKNzzqrmRtuI3oLZY6-VtjgXYi6kLF9lM1aUTS55IV5nM9qwOufpuMrehfBEaVHLhr_NrrgUvKCUz7JfD9BrZ9xOKzAEbE-2EB8viaXzHg1E7SzRlixs1Pm31UKcXp3rj_nBBR31M5L7aacQU5B069HuyEoHhICfyQMcdG-OZOvdzmMIE75Fr43rRgOebA6gkg7DaYGVHoYxIFmYZ3RTeQV72OH77M0AJuCHl_s6-_Hl9vvyLl9vvt4vF-tcVUzGnGOvJCqluoYjQo91JXslyropJaUCyjJFsuS87lANqlOVaihFaGgvleJQXGefzn0P3v0cMcR2r4NCY8CiG0PLasG4oFXZ_AfKWF1yWvOE1mdUeReCx6E9eL0Hf2wZbSdP2789bYVoJ0-T9OPLlLFLxYvwj4kJ2JyBpxDTR10A8FErg__szKpT__OIC6kewbdoi9-EbMRq</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Chino, Haruka</creator><creator>Sekine, Akimasa</creator><creator>Baba, Tomohisa</creator><creator>Iwasawa, Tae</creator><creator>Okudela, Koji</creator><creator>Takemura, Tamiko</creator><creator>Itoh, Harumi</creator><creator>Sato, Shinji</creator><creator>Suzuki, Yasuo</creator><creator>Ogura, Takashi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20160101</creationdate><title>Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage</title><author>Chino, Haruka ; Sekine, Akimasa ; Baba, Tomohisa ; Iwasawa, Tae ; Okudela, Koji ; Takemura, Tamiko ; Itoh, Harumi ; Sato, Shinji ; Suzuki, Yasuo ; Ogura, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-2edc7ecccb92eeade867dc548947005a44dc574228becfcbc6c900ea90d7cc2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>anti-melanoma differentiation-associated protein 5 antibody</topic><topic>Autoantibodies - blood</topic><topic>Biomarkers - blood</topic><topic>clinically amyopathic dermatomyositis</topic><topic>Cyclic N-Oxides - blood</topic><topic>Humans</topic><topic>Lung Diseases, Interstitial - blood</topic><topic>Lung Diseases, Interstitial - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>perilobular opacities</topic><topic>Pulmonary Alveoli</topic><topic>radiological and pathological correlation</topic><topic>rapidly-progressive interstitial lung disease</topic><topic>surgical lung biopsy</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chino, Haruka</creatorcontrib><creatorcontrib>Sekine, Akimasa</creatorcontrib><creatorcontrib>Baba, Tomohisa</creatorcontrib><creatorcontrib>Iwasawa, Tae</creatorcontrib><creatorcontrib>Okudela, Koji</creatorcontrib><creatorcontrib>Takemura, Tamiko</creatorcontrib><creatorcontrib>Itoh, Harumi</creatorcontrib><creatorcontrib>Sato, Shinji</creatorcontrib><creatorcontrib>Suzuki, Yasuo</creatorcontrib><creatorcontrib>Ogura, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chino, Haruka</au><au>Sekine, Akimasa</au><au>Baba, Tomohisa</au><au>Iwasawa, Tae</au><au>Okudela, Koji</au><au>Takemura, Tamiko</au><au>Itoh, Harumi</au><au>Sato, Shinji</au><au>Suzuki, Yasuo</au><au>Ogura, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>55</volume><issue>16</issue><spage>2241</spage><epage>2246</epage><pages>2241-2246</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>27523002</pmid><doi>10.2169/internalmedicine.55.5774</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2016/08/15, Vol.55(16), pp.2241-2246 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1851250649 |
| source | J-STAGE Free; MEDLINE; PubMed Central; PubMed Central Open Access |
| subjects | anti-melanoma differentiation-associated protein 5 antibody Autoantibodies - blood Biomarkers - blood clinically amyopathic dermatomyositis Cyclic N-Oxides - blood Humans Lung Diseases, Interstitial - blood Lung Diseases, Interstitial - diagnostic imaging Male Middle Aged perilobular opacities Pulmonary Alveoli radiological and pathological correlation rapidly-progressive interstitial lung disease surgical lung biopsy Tomography, X-Ray Computed |
| title | Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T12%3A00%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Radiological%20and%20Pathological%20Correlation%20in%20Anti-MDA5%20Antibody-positive%20Interstitial%20Lung%20Disease:%20Rapidly%20Progressive%20Perilobular%20Opacities%20and%20Diffuse%20Alveolar%20Damage&rft.jtitle=Internal%20Medicine&rft.au=Chino,%20Haruka&rft.date=2016-01-01&rft.volume=55&rft.issue=16&rft.spage=2241&rft.epage=2246&rft.pages=2241-2246&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.55.5774&rft_dat=%3Cproquest_cross%3E1811842082%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1811842082&rft_id=info:pmid/27523002&rfr_iscdi=true |