The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation

Nef, a multifunctional HIV protein, activates the Vav/Rac/p21-activated kinase (PAK) signaling pathway. Given the potential role of this pathway in the activation of the phagocyte NADPH oxidase, we have investigated the effect of the HIV-1 Nef protein on the phagocyte respiratory burst. Microglia (c...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (44), p.42136-42143
Hauptverfasser:	Vilhardt, Frederik, Plastre, Olivier, Sawada, Makoto, Suzuki, Kazuo, Wiznerowicz, Maciej, Kiyokawa, Etsuko, Trono, Didier, Krause, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cell Line Enzyme Activation Gene Products, nef - physiology HIV-1 - physiology Mice Microglia - enzymology NADPH Oxidases - metabolism nef Gene Products, Human Immunodeficiency Virus Oncogene Proteins - physiology Phagocytes - enzymology Protein Subunits Proto-Oncogene Proteins c-vav rac1 GTP-Binding Protein - physiology src Homology Domains Superoxides - metabolism
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